RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation

CASTOR1 is an arginine sensor that inhibits mTORC1 activation, for which this pathway is frequently dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1 phosphorylation and degradation to activate mTORC1 and promote tumorigenesis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Tingting Li, Xian Wang, Enguo Ju, Suzane Ramos da Silva, Luping Chen, Xinquan Zhang, Shan Wei, Shou-Jiang Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d106505773e4634b6f3104272c163b7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d106505773e4634b6f3104272c163b7
record_format	dspace
spelling	oai:doaj.org-article:5d106505773e4634b6f3104272c163b72021-12-02T14:21:30ZRNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation10.1038/s41467-021-21206-32041-1723https://doaj.org/article/5d106505773e4634b6f3104272c163b72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21206-3https://doaj.org/toc/2041-1723CASTOR1 is an arginine sensor that inhibits mTORC1 activation, for which this pathway is frequently dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1 phosphorylation and degradation to activate mTORC1 and promote tumorigenesis.Tingting LiXian WangEnguo JuSuzane Ramos da SilvaLuping ChenXinquan ZhangShan WeiShou-Jiang GaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tingting Li Xian Wang Enguo Ju Suzane Ramos da Silva Luping Chen Xinquan Zhang Shan Wei Shou-Jiang Gao RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
description	CASTOR1 is an arginine sensor that inhibits mTORC1 activation, for which this pathway is frequently dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1 phosphorylation and degradation to activate mTORC1 and promote tumorigenesis.
format	article
author	Tingting Li Xian Wang Enguo Ju Suzane Ramos da Silva Luping Chen Xinquan Zhang Shan Wei Shou-Jiang Gao
author_facet	Tingting Li Xian Wang Enguo Ju Suzane Ramos da Silva Luping Chen Xinquan Zhang Shan Wei Shou-Jiang Gao
author_sort	Tingting Li
title	RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
title_short	RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
title_full	RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
title_fullStr	RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
title_full_unstemmed	RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
title_sort	rnf167 activates mtorc1 and promotes tumorigenesis by targeting castor1 for ubiquitination and degradation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d106505773e4634b6f3104272c163b7
work_keys_str_mv	AT tingtingli rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT xianwang rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT enguoju rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT suzaneramosdasilva rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT lupingchen rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT xinquanzhang rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT shanwei rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation AT shoujianggao rnf167activatesmtorc1andpromotestumorigenesisbytargetingcastor1forubiquitinationanddegradation
_version_	1718391550232231936

RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation

Ejemplares similares