SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix

SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix

SP7/Osterix is a transcription factor involved in osteoblast differentiation. Here, the authors show that Sirtuin 7 activates Osterix posttranslationally by regulating its lysine acylation, and that mice lacking Sirtuin 7 in osteoblasts show reduced bone formation.

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Autores principales: Masatoshi Fukuda, Tatsuya Yoshizawa, Md. Fazlul Karim, Shihab U. Sobuz, Wataru Korogi, Daiki Kobayasi, Hiroki Okanishi, Masayoshi Tasaki, Katsuhiko Ono, Tomohiro Sawa, Yoshifumi Sato, Mami Chirifu, Takeshi Masuda, Teruya Nakamura, Hironori Tanoue, Kazuhisa Nakashima, Yoshihiro Kobashigawa, Hiroshi Morioka, Eva Bober, Sumio Ohtsuki, Yuriko Yamagata, Yukio Ando, Yuichi Oike, Norie Araki, Shu Takeda, Hiroshi Mizuta, Kazuya Yamagata
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5d154c78ddfa43f09911b245d2d21134
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spelling oai:doaj.org-article:5d154c78ddfa43f09911b245d2d211342021-12-02T16:56:37ZSIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix10.1038/s41467-018-05187-42041-1723https://doaj.org/article/5d154c78ddfa43f09911b245d2d211342018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05187-4https://doaj.org/toc/2041-1723SP7/Osterix is a transcription factor involved in osteoblast differentiation. Here, the authors show that Sirtuin 7 activates Osterix posttranslationally by regulating its lysine acylation, and that mice lacking Sirtuin 7 in osteoblasts show reduced bone formation.Masatoshi FukudaTatsuya YoshizawaMd. Fazlul KarimShihab U. SobuzWataru KorogiDaiki KobayasiHiroki OkanishiMasayoshi TasakiKatsuhiko OnoTomohiro SawaYoshifumi SatoMami ChirifuTakeshi MasudaTeruya NakamuraHironori TanoueKazuhisa NakashimaYoshihiro KobashigawaHiroshi MoriokaEva BoberSumio OhtsukiYuriko YamagataYukio AndoYuichi OikeNorie ArakiShu TakedaHiroshi MizutaKazuya YamagataNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Masatoshi Fukuda
Tatsuya Yoshizawa
Md. Fazlul Karim
Shihab U. Sobuz
Wataru Korogi
Daiki Kobayasi
Hiroki Okanishi
Masayoshi Tasaki
Katsuhiko Ono
Tomohiro Sawa
Yoshifumi Sato
Mami Chirifu
Takeshi Masuda
Teruya Nakamura
Hironori Tanoue
Kazuhisa Nakashima
Yoshihiro Kobashigawa
Hiroshi Morioka
Eva Bober
Sumio Ohtsuki
Yuriko Yamagata
Yukio Ando
Yuichi Oike
Norie Araki
Shu Takeda
Hiroshi Mizuta
Kazuya Yamagata
SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
description SP7/Osterix is a transcription factor involved in osteoblast differentiation. Here, the authors show that Sirtuin 7 activates Osterix posttranslationally by regulating its lysine acylation, and that mice lacking Sirtuin 7 in osteoblasts show reduced bone formation.
format article
author Masatoshi Fukuda
Tatsuya Yoshizawa
Md. Fazlul Karim
Shihab U. Sobuz
Wataru Korogi
Daiki Kobayasi
Hiroki Okanishi
Masayoshi Tasaki
Katsuhiko Ono
Tomohiro Sawa
Yoshifumi Sato
Mami Chirifu
Takeshi Masuda
Teruya Nakamura
Hironori Tanoue
Kazuhisa Nakashima
Yoshihiro Kobashigawa
Hiroshi Morioka
Eva Bober
Sumio Ohtsuki
Yuriko Yamagata
Yukio Ando
Yuichi Oike
Norie Araki
Shu Takeda
Hiroshi Mizuta
Kazuya Yamagata
author_facet Masatoshi Fukuda
Tatsuya Yoshizawa
Md. Fazlul Karim
Shihab U. Sobuz
Wataru Korogi
Daiki Kobayasi
Hiroki Okanishi
Masayoshi Tasaki
Katsuhiko Ono
Tomohiro Sawa
Yoshifumi Sato
Mami Chirifu
Takeshi Masuda
Teruya Nakamura
Hironori Tanoue
Kazuhisa Nakashima
Yoshihiro Kobashigawa
Hiroshi Morioka
Eva Bober
Sumio Ohtsuki
Yuriko Yamagata
Yukio Ando
Yuichi Oike
Norie Araki
Shu Takeda
Hiroshi Mizuta
Kazuya Yamagata
author_sort Masatoshi Fukuda
title SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
title_short SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
title_full SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
title_fullStr SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
title_full_unstemmed SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix
title_sort sirt7 has a critical role in bone formation by regulating lysine acylation of sp7/osterix
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/5d154c78ddfa43f09911b245d2d21134
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