Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

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Autores principales:	Edith Hofer, Gennady V. Roshchupkin, Hieab H. H. Adams, Maria J. Knol, Honghuang Lin, Shuo Li, Habil Zare, Shahzad Ahmad, Nicola J. Armstrong, Claudia L. Satizabal, Manon Bernard, Joshua C. Bis, Nathan A. Gillespie, Michelle Luciano, Aniket Mishra, Markus Scholz, Alexander Teumer, Rui Xia, Xueqiu Jian, Thomas H. Mosley, Yasaman Saba, Lukas Pirpamer, Stephan Seiler, James T. Becker, Owen Carmichael, Jerome I. Rotter, Bruce M. Psaty, Oscar L. Lopez, Najaf Amin, Sven J. van der Lee, Qiong Yang, Jayandra J. Himali, Pauline Maillard, Alexa S. Beiser, Charles DeCarli, Sherif Karama, Lindsay Lewis, Mat Harris, Mark E. Bastin, Ian J. Deary, A. Veronica Witte, Frauke Beyer, Markus Loeffler, Karen A. Mather, Peter R. Schofield, Anbupalam Thalamuthu, John B. Kwok, Margaret J. Wright, David Ames, Julian Trollor, Jiyang Jiang, Henry Brodaty, Wei Wen, Meike W. Vernooij, Albert Hofman, André G. Uitterlinden, Wiro J. Niessen, Katharina Wittfeld, Robin Bülow, Uwe Völker, Zdenka Pausova, G. Bruce Pike, Sophie Maingault, Fabrice Crivello, Christophe Tzourio, Philippe Amouyel, Bernard Mazoyer, Michael C. Neale, Carol E. Franz, Michael J. Lyons, Matthew S. Panizzon, Ole A. Andreassen, Anders M. Dale, Mark Logue, Katrina L. Grasby, Neda Jahanshad, Jodie N. Painter, Lucía Colodro-Conde, Janita Bralten, Derrek P. Hibar, Penelope A. Lind, Fabrizio Pizzagalli, Jason L. Stein, Paul M. Thompson, Sarah E. Medland, ENIGMA consortium, Perminder S. Sachdev, William S. Kremen, Joanna M. Wardlaw, Arno Villringer, Cornelia M. van Duijn, Hans J. Grabe, William T. Longstreth, Myriam Fornage, Tomas Paus, Stephanie Debette, M. Arfan Ikram, Helena Schmidt, Reinhold Schmidt, Sudha Seshadri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d16e85f224b486f9cfab04f0d940bed
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spelling	oai:doaj.org-article:5d16e85f224b486f9cfab04f0d940bed2021-12-02T15:14:37ZGenetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults10.1038/s41467-020-18367-y2041-1723https://doaj.org/article/5d16e85f224b486f9cfab04f0d940bed2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18367-yhttps://doaj.org/toc/2041-1723Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.Edith HoferGennady V. RoshchupkinHieab H. H. AdamsMaria J. KnolHonghuang LinShuo LiHabil ZareShahzad AhmadNicola J. ArmstrongClaudia L. SatizabalManon BernardJoshua C. BisNathan A. GillespieMichelle LucianoAniket MishraMarkus ScholzAlexander TeumerRui XiaXueqiu JianThomas H. MosleyYasaman SabaLukas PirpamerStephan SeilerJames T. BeckerOwen CarmichaelJerome I. RotterBruce M. PsatyOscar L. LopezNajaf AminSven J. van der LeeQiong YangJayandra J. HimaliPauline MaillardAlexa S. BeiserCharles DeCarliSherif KaramaLindsay LewisMat HarrisMark E. BastinIan J. DearyA. Veronica WitteFrauke BeyerMarkus LoefflerKaren A. MatherPeter R. SchofieldAnbupalam ThalamuthuJohn B. KwokMargaret J. WrightDavid AmesJulian TrollorJiyang JiangHenry BrodatyWei WenMeike W. VernooijAlbert HofmanAndré G. UitterlindenWiro J. NiessenKatharina WittfeldRobin BülowUwe VölkerZdenka PausovaG. Bruce PikeSophie MaingaultFabrice CrivelloChristophe TzourioPhilippe AmouyelBernard MazoyerMichael C. NealeCarol E. FranzMichael J. LyonsMatthew S. PanizzonOle A. AndreassenAnders M. DaleMark LogueKatrina L. GrasbyNeda JahanshadJodie N. PainterLucía Colodro-CondeJanita BraltenDerrek P. HibarPenelope A. LindFabrizio PizzagalliJason L. SteinPaul M. ThompsonSarah E. MedlandENIGMA consortiumPerminder S. SachdevWilliam S. KremenJoanna M. WardlawArno VillringerCornelia M. van DuijnHans J. GrabeWilliam T. LongstrethMyriam FornageTomas PausStephanie DebetteM. Arfan IkramHelena SchmidtReinhold SchmidtSudha SeshadriNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edith Hofer Gennady V. Roshchupkin Hieab H. H. Adams Maria J. Knol Honghuang Lin Shuo Li Habil Zare Shahzad Ahmad Nicola J. Armstrong Claudia L. Satizabal Manon Bernard Joshua C. Bis Nathan A. Gillespie Michelle Luciano Aniket Mishra Markus Scholz Alexander Teumer Rui Xia Xueqiu Jian Thomas H. Mosley Yasaman Saba Lukas Pirpamer Stephan Seiler James T. Becker Owen Carmichael Jerome I. Rotter Bruce M. Psaty Oscar L. Lopez Najaf Amin Sven J. van der Lee Qiong Yang Jayandra J. Himali Pauline Maillard Alexa S. Beiser Charles DeCarli Sherif Karama Lindsay Lewis Mat Harris Mark E. Bastin Ian J. Deary A. Veronica Witte Frauke Beyer Markus Loeffler Karen A. Mather Peter R. Schofield Anbupalam Thalamuthu John B. Kwok Margaret J. Wright David Ames Julian Trollor Jiyang Jiang Henry Brodaty Wei Wen Meike W. Vernooij Albert Hofman André G. Uitterlinden Wiro J. Niessen Katharina Wittfeld Robin Bülow Uwe Völker Zdenka Pausova G. Bruce Pike Sophie Maingault Fabrice Crivello Christophe Tzourio Philippe Amouyel Bernard Mazoyer Michael C. Neale Carol E. Franz Michael J. Lyons Matthew S. Panizzon Ole A. Andreassen Anders M. Dale Mark Logue Katrina L. Grasby Neda Jahanshad Jodie N. Painter Lucía Colodro-Conde Janita Bralten Derrek P. Hibar Penelope A. Lind Fabrizio Pizzagalli Jason L. Stein Paul M. Thompson Sarah E. Medland ENIGMA consortium Perminder S. Sachdev William S. Kremen Joanna M. Wardlaw Arno Villringer Cornelia M. van Duijn Hans J. Grabe William T. Longstreth Myriam Fornage Tomas Paus Stephanie Debette M. Arfan Ikram Helena Schmidt Reinhold Schmidt Sudha Seshadri Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
description	Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.
format	article
author	Edith Hofer Gennady V. Roshchupkin Hieab H. H. Adams Maria J. Knol Honghuang Lin Shuo Li Habil Zare Shahzad Ahmad Nicola J. Armstrong Claudia L. Satizabal Manon Bernard Joshua C. Bis Nathan A. Gillespie Michelle Luciano Aniket Mishra Markus Scholz Alexander Teumer Rui Xia Xueqiu Jian Thomas H. Mosley Yasaman Saba Lukas Pirpamer Stephan Seiler James T. Becker Owen Carmichael Jerome I. Rotter Bruce M. Psaty Oscar L. Lopez Najaf Amin Sven J. van der Lee Qiong Yang Jayandra J. Himali Pauline Maillard Alexa S. Beiser Charles DeCarli Sherif Karama Lindsay Lewis Mat Harris Mark E. Bastin Ian J. Deary A. Veronica Witte Frauke Beyer Markus Loeffler Karen A. Mather Peter R. Schofield Anbupalam Thalamuthu John B. Kwok Margaret J. Wright David Ames Julian Trollor Jiyang Jiang Henry Brodaty Wei Wen Meike W. Vernooij Albert Hofman André G. Uitterlinden Wiro J. Niessen Katharina Wittfeld Robin Bülow Uwe Völker Zdenka Pausova G. Bruce Pike Sophie Maingault Fabrice Crivello Christophe Tzourio Philippe Amouyel Bernard Mazoyer Michael C. Neale Carol E. Franz Michael J. Lyons Matthew S. Panizzon Ole A. Andreassen Anders M. Dale Mark Logue Katrina L. Grasby Neda Jahanshad Jodie N. Painter Lucía Colodro-Conde Janita Bralten Derrek P. Hibar Penelope A. Lind Fabrizio Pizzagalli Jason L. Stein Paul M. Thompson Sarah E. Medland ENIGMA consortium Perminder S. Sachdev William S. Kremen Joanna M. Wardlaw Arno Villringer Cornelia M. van Duijn Hans J. Grabe William T. Longstreth Myriam Fornage Tomas Paus Stephanie Debette M. Arfan Ikram Helena Schmidt Reinhold Schmidt Sudha Seshadri
author_facet	Edith Hofer Gennady V. Roshchupkin Hieab H. H. Adams Maria J. Knol Honghuang Lin Shuo Li Habil Zare Shahzad Ahmad Nicola J. Armstrong Claudia L. Satizabal Manon Bernard Joshua C. Bis Nathan A. Gillespie Michelle Luciano Aniket Mishra Markus Scholz Alexander Teumer Rui Xia Xueqiu Jian Thomas H. Mosley Yasaman Saba Lukas Pirpamer Stephan Seiler James T. Becker Owen Carmichael Jerome I. Rotter Bruce M. Psaty Oscar L. Lopez Najaf Amin Sven J. van der Lee Qiong Yang Jayandra J. Himali Pauline Maillard Alexa S. Beiser Charles DeCarli Sherif Karama Lindsay Lewis Mat Harris Mark E. Bastin Ian J. Deary A. Veronica Witte Frauke Beyer Markus Loeffler Karen A. Mather Peter R. Schofield Anbupalam Thalamuthu John B. Kwok Margaret J. Wright David Ames Julian Trollor Jiyang Jiang Henry Brodaty Wei Wen Meike W. Vernooij Albert Hofman André G. Uitterlinden Wiro J. Niessen Katharina Wittfeld Robin Bülow Uwe Völker Zdenka Pausova G. Bruce Pike Sophie Maingault Fabrice Crivello Christophe Tzourio Philippe Amouyel Bernard Mazoyer Michael C. Neale Carol E. Franz Michael J. Lyons Matthew S. Panizzon Ole A. Andreassen Anders M. Dale Mark Logue Katrina L. Grasby Neda Jahanshad Jodie N. Painter Lucía Colodro-Conde Janita Bralten Derrek P. Hibar Penelope A. Lind Fabrizio Pizzagalli Jason L. Stein Paul M. Thompson Sarah E. Medland ENIGMA consortium Perminder S. Sachdev William S. Kremen Joanna M. Wardlaw Arno Villringer Cornelia M. van Duijn Hans J. Grabe William T. Longstreth Myriam Fornage Tomas Paus Stephanie Debette M. Arfan Ikram Helena Schmidt Reinhold Schmidt Sudha Seshadri
author_sort	Edith Hofer
title	Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
title_short	Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
title_full	Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
title_fullStr	Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
title_full_unstemmed	Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
title_sort	genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5d16e85f224b486f9cfab04f0d940bed
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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

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