Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets

This experiment was conducted to determine the effect of dietary supplementation with copper sulfate and cupreous N-carbamylglutamate chelate (NCG-Cu) on the growth performance, serum biochemical profile, immune response, tissue mineral distributions, and fecal excretion of minerals in nursery pigle...

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Autores principales:	Peng Liao, Xugang Shu, Min Tang, Bie Tan, Yulong Yin
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	n-carbamylglutamate chelate copper source growth performance fecal cu excretion nursery piglets Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5d2000112ad842d880251008a082980f
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spelling	oai:doaj.org-article:5d2000112ad842d880251008a082980f2021-11-26T11:19:46ZEffect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets0954-01051465-344310.1080/09540105.2017.1416068https://doaj.org/article/5d2000112ad842d880251008a082980f2018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1416068https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443This experiment was conducted to determine the effect of dietary supplementation with copper sulfate and cupreous N-carbamylglutamate chelate (NCG-Cu) on the growth performance, serum biochemical profile, immune response, tissue mineral distributions, and fecal excretion of minerals in nursery piglets. Eighteen healthy nursery piglets were randomly assigned to 3 dietary treatments consisting of no copper in either form (control), 650 g/t copper sulfate (650 g/t Cu) or 320 g/t NCG-Cu (320 g/t NCG-Cu) for 35 days. Pigs fed the 320 g/t NCG-Cu diet showed a significantly (P < 0.05) elevated growth rate, feed conversion efficiency, IgA and IgM levels, and decreased diarrhea rate compared to those fed the 650 g/t Cu diet. Fecal copper (Cu) and zinc (Zn) were increased (P < 0.05) when pigs were fed the 650 g/t Cu diets compared with those fed the 320 g/t NCG-Cu diets. Tissue Cu has limited effects on tissue mineral distribution, except for the distribution in the spleen and liver (P < 0.05). These results indicated that 320 g/t NCG-Cu (chelated) was as effective as 650 g/t Cu (inorganic Cu) for stimulating growth and the immune response and reducing dietary fecal Cu excretion, thus reducing environmental pollution. Abbreviations: NCG: N-carbamylglutamate chelate; ADG: average daily gain; ADFI: average daily feed intake; F/G: feed to gain ratio; ALB: albumin; GLU: blood glucose; CREA: creatinine; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate amino transferase; GLB: globulin; TC: total cholesterol; TP: total protein; urea: Urea; D-BIL: direct-acting-bilirubin; T-BIL: total bilirubin; UA: urate; CK: creatine kinase; LDH: lactate dehydrogenase; IgG: immunoglobulin G; IgA: immunoglobulin A; IgM: immunoglobulin M; C3: complement C3; LD: longissimus dorsi; ICP-OES: inductively coupled plasma optical emission spectrometry; AA: amino acid; GIT: gastrointestinal; Cu-Met: Cu-methionine; CP: crude protein; NDF: neutral detergent fiber; ADF: acid detergent fiber.Peng LiaoXugang ShuMin TangBie TanYulong YinTaylor & Francis Grouparticlen-carbamylglutamate chelatecopper sourcegrowth performancefecal cu excretionnursery pigletsAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 548-563 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	n-carbamylglutamate chelate copper source growth performance fecal cu excretion nursery piglets Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	n-carbamylglutamate chelate copper source growth performance fecal cu excretion nursery piglets Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Peng Liao Xugang Shu Min Tang Bie Tan Yulong Yin Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
description	This experiment was conducted to determine the effect of dietary supplementation with copper sulfate and cupreous N-carbamylglutamate chelate (NCG-Cu) on the growth performance, serum biochemical profile, immune response, tissue mineral distributions, and fecal excretion of minerals in nursery piglets. Eighteen healthy nursery piglets were randomly assigned to 3 dietary treatments consisting of no copper in either form (control), 650 g/t copper sulfate (650 g/t Cu) or 320 g/t NCG-Cu (320 g/t NCG-Cu) for 35 days. Pigs fed the 320 g/t NCG-Cu diet showed a significantly (P < 0.05) elevated growth rate, feed conversion efficiency, IgA and IgM levels, and decreased diarrhea rate compared to those fed the 650 g/t Cu diet. Fecal copper (Cu) and zinc (Zn) were increased (P < 0.05) when pigs were fed the 650 g/t Cu diets compared with those fed the 320 g/t NCG-Cu diets. Tissue Cu has limited effects on tissue mineral distribution, except for the distribution in the spleen and liver (P < 0.05). These results indicated that 320 g/t NCG-Cu (chelated) was as effective as 650 g/t Cu (inorganic Cu) for stimulating growth and the immune response and reducing dietary fecal Cu excretion, thus reducing environmental pollution. Abbreviations: NCG: N-carbamylglutamate chelate; ADG: average daily gain; ADFI: average daily feed intake; F/G: feed to gain ratio; ALB: albumin; GLU: blood glucose; CREA: creatinine; ALP: alkaline phosphatase; ALT: alanine aminotransferase; AST: aspartate amino transferase; GLB: globulin; TC: total cholesterol; TP: total protein; urea: Urea; D-BIL: direct-acting-bilirubin; T-BIL: total bilirubin; UA: urate; CK: creatine kinase; LDH: lactate dehydrogenase; IgG: immunoglobulin G; IgA: immunoglobulin A; IgM: immunoglobulin M; C3: complement C3; LD: longissimus dorsi; ICP-OES: inductively coupled plasma optical emission spectrometry; AA: amino acid; GIT: gastrointestinal; Cu-Met: Cu-methionine; CP: crude protein; NDF: neutral detergent fiber; ADF: acid detergent fiber.
format	article
author	Peng Liao Xugang Shu Min Tang Bie Tan Yulong Yin
author_facet	Peng Liao Xugang Shu Min Tang Bie Tan Yulong Yin
author_sort	Peng Liao
title	Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
title_short	Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
title_full	Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
title_fullStr	Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
title_full_unstemmed	Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
title_sort	effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/5d2000112ad842d880251008a082980f
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Effect of dietary copper source (inorganic vs. chelated) on immune response, mineral status, and fecal mineral excretion in nursery piglets

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