Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

Bmal1 is a key transcription factor that controls rhythmicity of diverse biological functions. Here, Pan et al. show that Bmal1 deficiency in mice increases lipoprotein secretion and reduces cholesterol excretion to bile, and decipher the molecular mechanisms underlying hyperlipidaemia and atheroscl...

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Autores principales:	Xiaoyue Pan, Christopher A. Bradfield, M. Mahmood Hussain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d25eda762324993b3982405584bf5c7
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spelling	oai:doaj.org-article:5d25eda762324993b3982405584bf5c72021-12-02T15:35:24ZGlobal and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis10.1038/ncomms130112041-1723https://doaj.org/article/5d25eda762324993b3982405584bf5c72016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13011https://doaj.org/toc/2041-1723Bmal1 is a key transcription factor that controls rhythmicity of diverse biological functions. Here, Pan et al. show that Bmal1 deficiency in mice increases lipoprotein secretion and reduces cholesterol excretion to bile, and decipher the molecular mechanisms underlying hyperlipidaemia and atherosclerosis promoted by the lack of Bmal1.Xiaoyue PanChristopher A. BradfieldM. Mahmood HussainNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoyue Pan Christopher A. Bradfield M. Mahmood Hussain Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
description	Bmal1 is a key transcription factor that controls rhythmicity of diverse biological functions. Here, Pan et al. show that Bmal1 deficiency in mice increases lipoprotein secretion and reduces cholesterol excretion to bile, and decipher the molecular mechanisms underlying hyperlipidaemia and atherosclerosis promoted by the lack of Bmal1.
format	article
author	Xiaoyue Pan Christopher A. Bradfield M. Mahmood Hussain
author_facet	Xiaoyue Pan Christopher A. Bradfield M. Mahmood Hussain
author_sort	Xiaoyue Pan
title	Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
title_short	Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
title_full	Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
title_fullStr	Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
title_full_unstemmed	Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis
title_sort	global and hepatocyte-specific ablation of bmal1 induces hyperlipidaemia and enhances atherosclerosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5d25eda762324993b3982405584bf5c7
work_keys_str_mv	AT xiaoyuepan globalandhepatocytespecificablationofbmal1induceshyperlipidaemiaandenhancesatherosclerosis AT christopherabradfield globalandhepatocytespecificablationofbmal1induceshyperlipidaemiaandenhancesatherosclerosis AT mmahmoodhussain globalandhepatocytespecificablationofbmal1induceshyperlipidaemiaandenhancesatherosclerosis
_version_	1718386598288031744

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

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