A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

Abstract Background Cognitive impairment, an increasing mental health issue, is a core feature of the aging brain and neurodegenerative diseases. Industrialized nations especially, have experienced a marked decrease in dietary fiber intake, but the potential mechanism linking low fiber intake and co...

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Main Authors: Hongli Shi, Xing Ge, Xi Ma, Mingxuan Zheng, Xiaoying Cui, Wei Pan, Peng Zheng, Xiaoying Yang, Peng Zhang, Minmin Hu, Tao Hu, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Format: article
Language:EN
Published: BMC 2021
Subjects:
Dietary fiber deficiency
Cognition
Gut microbiota
Short-chain fatty acids
Gut-brain axis
Microbial ecology
QR100-130
Online Access:https://doaj.org/article/5d2be85991864c34ada39ed64453dae8
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https://doaj.org/article/5d2be85991864c34ada39ed64453dae8

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