Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice

Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice

Ketamine is used for sedation and treatment of depression, but is also a drug of abuse. Here the authors show that ketamine modulates the endocannabinoid system in mice, and that this may contribute to its psychoactive effects.

Guardado en:
Detalles Bibliográficos
Autores principales: Wei Xu, Hongchun Li, Liang Wang, Jiamei Zhang, Chunqi Liu, Xuemei Wan, Xiaochong Liu, Yiming Hu, Qiyao Fang, Yuanyuan Xiao, Qian Bu, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/5d2e1408f3a74c629dd722b4d53c0d12
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:5d2e1408f3a74c629dd722b4d53c0d12
record_format dspace
spelling oai:doaj.org-article:5d2e1408f3a74c629dd722b4d53c0d122021-12-02T10:48:11ZEndocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice10.1038/s41467-020-19780-z2041-1723https://doaj.org/article/5d2e1408f3a74c629dd722b4d53c0d122020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19780-zhttps://doaj.org/toc/2041-1723Ketamine is used for sedation and treatment of depression, but is also a drug of abuse. Here the authors show that ketamine modulates the endocannabinoid system in mice, and that this may contribute to its psychoactive effects.Wei XuHongchun LiLiang WangJiamei ZhangChunqi LiuXuemei WanXiaochong LiuYiming HuQiyao FangYuanyuan XiaoQian BuHongbo WangJingwei TianYinglan ZhaoXiaobo CenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wei Xu
Hongchun Li
Liang Wang
Jiamei Zhang
Chunqi Liu
Xuemei Wan
Xiaochong Liu
Yiming Hu
Qiyao Fang
Yuanyuan Xiao
Qian Bu
Hongbo Wang
Jingwei Tian
Yinglan Zhao
Xiaobo Cen
Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
description Ketamine is used for sedation and treatment of depression, but is also a drug of abuse. Here the authors show that ketamine modulates the endocannabinoid system in mice, and that this may contribute to its psychoactive effects.
format article
author Wei Xu
Hongchun Li
Liang Wang
Jiamei Zhang
Chunqi Liu
Xuemei Wan
Xiaochong Liu
Yiming Hu
Qiyao Fang
Yuanyuan Xiao
Qian Bu
Hongbo Wang
Jingwei Tian
Yinglan Zhao
Xiaobo Cen
author_facet Wei Xu
Hongchun Li
Liang Wang
Jiamei Zhang
Chunqi Liu
Xuemei Wan
Xiaochong Liu
Yiming Hu
Qiyao Fang
Yuanyuan Xiao
Qian Bu
Hongbo Wang
Jingwei Tian
Yinglan Zhao
Xiaobo Cen
author_sort Wei Xu
title Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
title_short Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
title_full Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
title_fullStr Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
title_full_unstemmed Endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
title_sort endocannabinoid signaling regulates the reinforcing and psychostimulant effects of ketamine in mice
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/5d2e1408f3a74c629dd722b4d53c0d12
work_keys_str_mv AT weixu endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT hongchunli endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT liangwang endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT jiameizhang endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT chunqiliu endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT xuemeiwan endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT xiaochongliu endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT yiminghu endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT qiyaofang endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT yuanyuanxiao endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT qianbu endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT hongbowang endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT jingweitian endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT yinglanzhao endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
AT xiaobocen endocannabinoidsignalingregulatesthereinforcingandpsychostimulanteffectsofketamineinmice
_version_ 1718396648443346944

Ejemplares similares