Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.

Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-f...

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Autores principales:	Hiromasa Funato, Satoko Oda, Junko Yokofujita, Hiroaki Igarashi, Masaru Kuroda
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d2f8943ff264d378fd18b6a474aa314
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spelling	oai:doaj.org-article:5d2f8943ff264d378fd18b6a474aa3142021-11-18T06:55:40ZFasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.1932-620310.1371/journal.pone.0018950https://doaj.org/article/5d2f8943ff264d378fd18b6a474aa3142011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21526203/?tool=EBIhttps://doaj.org/toc/1932-6203Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-fat diets, the medial hypothalamus changes the expression of neuropeptides regulating feeding, metabolism, and reproductive behaviors. Histone deacetylases (HDACs) are involved in the epigenetic control of gene expression and alter behavior in response to a variety of environmental factors. Here, we examined the expression of HDAC family members in the medial hypothalamus of mice in response to either fasting or a high-fat diet. In response to fasting, HDAC3 and -4 expression levels increased while HDAC10 and -11 levels decreased. Four weeks on a high-fat diet resulted in the increased expression of HDAC5 and -8. Moreover, fasting decreased the number of acetylated histone H3- and acetylated histone H4-positive cells in the ventrolateral subdivision of the ventromedial hypothalamus. Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states.Hiromasa FunatoSatoko OdaJunko YokofujitaHiroaki IgarashiMasaru KurodaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e18950 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiromasa Funato Satoko Oda Junko Yokofujita Hiroaki Igarashi Masaru Kuroda Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
description	Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Epigenetic factors also influence feeding behavior and metabolic phenotypes, such as obesity and insulin sensitivity. In response to fasting and high-fat diets, the medial hypothalamus changes the expression of neuropeptides regulating feeding, metabolism, and reproductive behaviors. Histone deacetylases (HDACs) are involved in the epigenetic control of gene expression and alter behavior in response to a variety of environmental factors. Here, we examined the expression of HDAC family members in the medial hypothalamus of mice in response to either fasting or a high-fat diet. In response to fasting, HDAC3 and -4 expression levels increased while HDAC10 and -11 levels decreased. Four weeks on a high-fat diet resulted in the increased expression of HDAC5 and -8. Moreover, fasting decreased the number of acetylated histone H3- and acetylated histone H4-positive cells in the ventrolateral subdivision of the ventromedial hypothalamus. Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states.
format	article
author	Hiromasa Funato Satoko Oda Junko Yokofujita Hiroaki Igarashi Masaru Kuroda
author_facet	Hiromasa Funato Satoko Oda Junko Yokofujita Hiroaki Igarashi Masaru Kuroda
author_sort	Hiromasa Funato
title	Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
title_short	Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
title_full	Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
title_fullStr	Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
title_full_unstemmed	Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
title_sort	fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5d2f8943ff264d378fd18b6a474aa314
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Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus.

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