PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

Protein phosphatase Cdc25 controls cell cycle transitions by dephosphorylating CDK substrates. Here, the authors show that the Cdc25A isoform regulates glycolysis through dephosphorylation of pyruvate kinase PKM2, resulting in β-catenin activation and consequent upregulation of the transcription of...

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Autores principales:	Ji Liang, Ruixiu Cao, Yajuan Zhang, Yan Xia, Yanhua Zheng, Xinjian Li, Liwei Wang, Weiwei Yang, Zhimin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d3275252c584869916d164239c89daf
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id	oai:doaj.org-article:5d3275252c584869916d164239c89daf
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spelling	oai:doaj.org-article:5d3275252c584869916d164239c89daf2021-12-02T17:33:21ZPKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis10.1038/ncomms124312041-1723https://doaj.org/article/5d3275252c584869916d164239c89daf2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12431https://doaj.org/toc/2041-1723Protein phosphatase Cdc25 controls cell cycle transitions by dephosphorylating CDK substrates. Here, the authors show that the Cdc25A isoform regulates glycolysis through dephosphorylation of pyruvate kinase PKM2, resulting in β-catenin activation and consequent upregulation of the transcription of glycolytic genes.Ji LiangRuixiu CaoYajuan ZhangYan XiaYanhua ZhengXinjian LiLiwei WangWeiwei YangZhimin LuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji Liang Ruixiu Cao Yajuan Zhang Yan Xia Yanhua Zheng Xinjian Li Liwei Wang Weiwei Yang Zhimin Lu PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
description	Protein phosphatase Cdc25 controls cell cycle transitions by dephosphorylating CDK substrates. Here, the authors show that the Cdc25A isoform regulates glycolysis through dephosphorylation of pyruvate kinase PKM2, resulting in β-catenin activation and consequent upregulation of the transcription of glycolytic genes.
format	article
author	Ji Liang Ruixiu Cao Yajuan Zhang Yan Xia Yanhua Zheng Xinjian Li Liwei Wang Weiwei Yang Zhimin Lu
author_facet	Ji Liang Ruixiu Cao Yajuan Zhang Yan Xia Yanhua Zheng Xinjian Li Liwei Wang Weiwei Yang Zhimin Lu
author_sort	Ji Liang
title	PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
title_short	PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
title_full	PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
title_fullStr	PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
title_full_unstemmed	PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis
title_sort	pkm2 dephosphorylation by cdc25a promotes the warburg effect and tumorigenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5d3275252c584869916d164239c89daf
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PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

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