m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia

Recent studies have demonstrated epigenetic regulation of immune responses. Nevertheless, the underlying effect of RNA N6-methyladenosine (m6A) modifications on tumor microenvironment cell infiltration remains elusive. In this study, we thoroughly assessed m6A modification patterns of 255 myeloid le...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ashuai Du, Xin Wu, Yunmei Gao, Baili Jiang, Jianlong Wang, Pan Zhang, Qiangqiang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	m6A tumor microenvironment AML immunotherapy mutation burden Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5d32f316590a47e397c1cdd78f3f7ec1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d32f316590a47e397c1cdd78f3f7ec1
record_format	dspace
spelling	oai:doaj.org-article:5d32f316590a47e397c1cdd78f3f7ec12021-11-30T13:16:29Zm6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia1664-322410.3389/fimmu.2021.789914https://doaj.org/article/5d32f316590a47e397c1cdd78f3f7ec12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.789914/fullhttps://doaj.org/toc/1664-3224Recent studies have demonstrated epigenetic regulation of immune responses. Nevertheless, the underlying effect of RNA N6-methyladenosine (m6A) modifications on tumor microenvironment cell infiltration remains elusive. In this study, we thoroughly assessed m6A modification patterns of 255 myeloid leukemia specimens based on 23 m6A regulators. Consensus clustering of the 23 m6A regulators was performed to determine three distinct m6A modification patterns that were remarkably consistent with three immunophenotypes of tumors: immunorejection, immune activation, and immune inertness. Further evaluation and prognostic analysis of the m6A modification patterns of individual tumors revealed that low m6A score was characterized by increased mutational burden, immune activation, and survival rates, whereas high m6A score was characterized by poorer survival rates and the absence of effective immune infiltration. In addition, this study investigated the association between m6A regulators and antitumor immune responses and discovered higher expression of the immune regulators PD-L1, PD-L2, MRP1, and MRP2 in low m6A scores. Generally, the expression pattern of m6A regulators was remarkably associated with prognostic results and antitumor immune responses in acute myeloid leukemia and may be an underlying target and biological marker for immune therapies.Ashuai DuAshuai DuXin WuYunmei GaoBaili JiangJianlong WangPan ZhangQiangqiang ZhaoQiangqiang ZhaoFrontiers Media S.A.articlem6Atumor microenvironmentAMLimmunotherapymutation burdenImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	m6A tumor microenvironment AML immunotherapy mutation burden Immunologic diseases. Allergy RC581-607
spellingShingle	m6A tumor microenvironment AML immunotherapy mutation burden Immunologic diseases. Allergy RC581-607 Ashuai Du Ashuai Du Xin Wu Yunmei Gao Baili Jiang Jianlong Wang Pan Zhang Qiangqiang Zhao Qiangqiang Zhao m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia
description	Recent studies have demonstrated epigenetic regulation of immune responses. Nevertheless, the underlying effect of RNA N6-methyladenosine (m6A) modifications on tumor microenvironment cell infiltration remains elusive. In this study, we thoroughly assessed m6A modification patterns of 255 myeloid leukemia specimens based on 23 m6A regulators. Consensus clustering of the 23 m6A regulators was performed to determine three distinct m6A modification patterns that were remarkably consistent with three immunophenotypes of tumors: immunorejection, immune activation, and immune inertness. Further evaluation and prognostic analysis of the m6A modification patterns of individual tumors revealed that low m6A score was characterized by increased mutational burden, immune activation, and survival rates, whereas high m6A score was characterized by poorer survival rates and the absence of effective immune infiltration. In addition, this study investigated the association between m6A regulators and antitumor immune responses and discovered higher expression of the immune regulators PD-L1, PD-L2, MRP1, and MRP2 in low m6A scores. Generally, the expression pattern of m6A regulators was remarkably associated with prognostic results and antitumor immune responses in acute myeloid leukemia and may be an underlying target and biological marker for immune therapies.
format	article
author	Ashuai Du Ashuai Du Xin Wu Yunmei Gao Baili Jiang Jianlong Wang Pan Zhang Qiangqiang Zhao Qiangqiang Zhao
author_facet	Ashuai Du Ashuai Du Xin Wu Yunmei Gao Baili Jiang Jianlong Wang Pan Zhang Qiangqiang Zhao Qiangqiang Zhao
author_sort	Ashuai Du
title	m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia
title_short	m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia
title_full	m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia
title_fullStr	m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia
title_full_unstemmed	m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia
title_sort	m6a regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in acute myeloid leukemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d32f316590a47e397c1cdd78f3f7ec1
work_keys_str_mv	AT ashuaidu m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT ashuaidu m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT xinwu m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT yunmeigao m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT bailijiang m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT jianlongwang m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT panzhang m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT qiangqiangzhao m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia AT qiangqiangzhao m6aregulatormediatedmethylationmodificationpatternsandtumormicroenvironmentinfiltrationcharacterizationinacutemyeloidleukemia
_version_	1718406564621058048

m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia

Ejemplares similares