Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases

The receptor interacting protein kinases 1/3 (RIPK1/3) have emerged as the key mediators in cell death pathways and inflammatory signaling, whose ubiquitination, phosphorylation, and inhibition could regulate the necroptosis and apoptosis effectually. Recently, more and more studies show great inter...

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Autores principales:	Yiming Leng, Ying Zhang, Xinyu Li, Zeyu Wang, Quan Zhuang, Yao Lu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	RIPK1 RIPK3 cardiovascular diseases necroptosis therapeutic Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5d343e3d5b5044259eb101c1571864bc
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spelling	oai:doaj.org-article:5d343e3d5b5044259eb101c1571864bc2021-11-18T09:52:51ZReceptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases1663-981210.3389/fphar.2021.762334https://doaj.org/article/5d343e3d5b5044259eb101c1571864bc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.762334/fullhttps://doaj.org/toc/1663-9812The receptor interacting protein kinases 1/3 (RIPK1/3) have emerged as the key mediators in cell death pathways and inflammatory signaling, whose ubiquitination, phosphorylation, and inhibition could regulate the necroptosis and apoptosis effectually. Recently, more and more studies show great interest in the mechanisms and the regulator of RIPK1/3-mediated inflammatory response and in the physiopathogenesis of cardiovascular diseases. The crosstalk of autophagy and necroptosis in cardiomyocyte death is a nonnegligible conversation of cell death. We elaborated on RIPK1/3-mediated necroptosis, pathways involved, the latest regulatory molecules and therapeutic targets in terms of ischemia reperfusion, myocardial remodeling, myocarditis, atherosclerosis, abdominal aortic aneurysm, and cardiovascular transplantation, etc.Yiming LengYing ZhangXinyu LiZeyu WangQuan ZhuangQuan ZhuangYao LuFrontiers Media S.A.articleRIPK1RIPK3cardiovascular diseasesnecroptosistherapeuticTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RIPK1 RIPK3 cardiovascular diseases necroptosis therapeutic Therapeutics. Pharmacology RM1-950
spellingShingle	RIPK1 RIPK3 cardiovascular diseases necroptosis therapeutic Therapeutics. Pharmacology RM1-950 Yiming Leng Ying Zhang Xinyu Li Zeyu Wang Quan Zhuang Quan Zhuang Yao Lu Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases
description	The receptor interacting protein kinases 1/3 (RIPK1/3) have emerged as the key mediators in cell death pathways and inflammatory signaling, whose ubiquitination, phosphorylation, and inhibition could regulate the necroptosis and apoptosis effectually. Recently, more and more studies show great interest in the mechanisms and the regulator of RIPK1/3-mediated inflammatory response and in the physiopathogenesis of cardiovascular diseases. The crosstalk of autophagy and necroptosis in cardiomyocyte death is a nonnegligible conversation of cell death. We elaborated on RIPK1/3-mediated necroptosis, pathways involved, the latest regulatory molecules and therapeutic targets in terms of ischemia reperfusion, myocardial remodeling, myocarditis, atherosclerosis, abdominal aortic aneurysm, and cardiovascular transplantation, etc.
format	article
author	Yiming Leng Ying Zhang Xinyu Li Zeyu Wang Quan Zhuang Quan Zhuang Yao Lu
author_facet	Yiming Leng Ying Zhang Xinyu Li Zeyu Wang Quan Zhuang Quan Zhuang Yao Lu
author_sort	Yiming Leng
title	Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases
title_short	Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases
title_full	Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases
title_fullStr	Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases
title_full_unstemmed	Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases
title_sort	receptor interacting protein kinases 1/3: the potential therapeutic target for cardiovascular inflammatory diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d343e3d5b5044259eb101c1571864bc
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Receptor Interacting Protein Kinases 1/3: The Potential Therapeutic Target for Cardiovascular Inflammatory Diseases

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