Mouse lipidomics reveals inherent flexibility of a mammalian lipidome

Abstract Lipidomics has become an indispensable method for the quantitative assessment of lipid metabolism in basic, clinical, and pharmaceutical research. It allows for the generation of information-dense datasets in a large variety of experimental setups and model organisms. Previous studies, most...

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Autores principales:	Michał A. Surma, Mathias J. Gerl, Ronny Herzog, Jussi Helppi, Kai Simons, Christian Klose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d352df926704e4c890080da404af29f
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spelling	oai:doaj.org-article:5d352df926704e4c890080da404af29f2021-12-02T18:51:14ZMouse lipidomics reveals inherent flexibility of a mammalian lipidome10.1038/s41598-021-98702-52045-2322https://doaj.org/article/5d352df926704e4c890080da404af29f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98702-5https://doaj.org/toc/2045-2322Abstract Lipidomics has become an indispensable method for the quantitative assessment of lipid metabolism in basic, clinical, and pharmaceutical research. It allows for the generation of information-dense datasets in a large variety of experimental setups and model organisms. Previous studies, mostly conducted in mice (Mus musculus), have shown a remarkable specificity of the lipid compositions of different cell types, tissues, and organs. However, a systematic analysis of the overall variation of the mouse lipidome is lacking. To fill this gap, in the present study, the effect of diet, sex, and genotype on the lipidomes of mouse tissues, organs, and bodily fluids has been investigated. Baseline quantitative lipidomes consisting of 796 individual lipid molecules belonging to 24 lipid classes are provided for 10 different sample types. Furthermore, the susceptibility of lipidomes to the tested parameters is assessed, providing insights into the organ-specific lipidomic plasticity and flexibility. This dataset provides a valuable resource for basic and pharmaceutical researchers working with murine models and complements existing proteomic and transcriptomic datasets. It will inform experimental design and facilitate interpretation of lipidomic datasets.Michał A. SurmaMathias J. GerlRonny HerzogJussi HelppiKai SimonsChristian KloseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michał A. Surma Mathias J. Gerl Ronny Herzog Jussi Helppi Kai Simons Christian Klose Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
description	Abstract Lipidomics has become an indispensable method for the quantitative assessment of lipid metabolism in basic, clinical, and pharmaceutical research. It allows for the generation of information-dense datasets in a large variety of experimental setups and model organisms. Previous studies, mostly conducted in mice (Mus musculus), have shown a remarkable specificity of the lipid compositions of different cell types, tissues, and organs. However, a systematic analysis of the overall variation of the mouse lipidome is lacking. To fill this gap, in the present study, the effect of diet, sex, and genotype on the lipidomes of mouse tissues, organs, and bodily fluids has been investigated. Baseline quantitative lipidomes consisting of 796 individual lipid molecules belonging to 24 lipid classes are provided for 10 different sample types. Furthermore, the susceptibility of lipidomes to the tested parameters is assessed, providing insights into the organ-specific lipidomic plasticity and flexibility. This dataset provides a valuable resource for basic and pharmaceutical researchers working with murine models and complements existing proteomic and transcriptomic datasets. It will inform experimental design and facilitate interpretation of lipidomic datasets.
format	article
author	Michał A. Surma Mathias J. Gerl Ronny Herzog Jussi Helppi Kai Simons Christian Klose
author_facet	Michał A. Surma Mathias J. Gerl Ronny Herzog Jussi Helppi Kai Simons Christian Klose
author_sort	Michał A. Surma
title	Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
title_short	Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
title_full	Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
title_fullStr	Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
title_full_unstemmed	Mouse lipidomics reveals inherent flexibility of a mammalian lipidome
title_sort	mouse lipidomics reveals inherent flexibility of a mammalian lipidome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d352df926704e4c890080da404af29f
work_keys_str_mv	AT michałasurma mouselipidomicsrevealsinherentflexibilityofamammalianlipidome AT mathiasjgerl mouselipidomicsrevealsinherentflexibilityofamammalianlipidome AT ronnyherzog mouselipidomicsrevealsinherentflexibilityofamammalianlipidome AT jussihelppi mouselipidomicsrevealsinherentflexibilityofamammalianlipidome AT kaisimons mouselipidomicsrevealsinherentflexibilityofamammalianlipidome AT christianklose mouselipidomicsrevealsinherentflexibilityofamammalianlipidome
_version_	1718377448635105280

Mouse lipidomics reveals inherent flexibility of a mammalian lipidome

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