Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis

Abstract Esophageal and gastric cancers share some risk factors. This study aimed to compare the long-term trends in mortality rates of esophageal and gastric cancers in China to provide evidence for cancer prevention and control. Mortality data were derived from 103 continuous points of the Disease...

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Autores principales:	Mengmeng Li, Xia Wan, Yanhong Wang, Yuanyuan Sun, Gonghuan Yang, Li Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d3831f2a0104d30811e60004d9e0f4b
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spelling	oai:doaj.org-article:5d3831f2a0104d30811e60004d9e0f4b2021-12-02T12:32:52ZTime trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis10.1038/s41598-017-07071-52045-2322https://doaj.org/article/5d3831f2a0104d30811e60004d9e0f4b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07071-5https://doaj.org/toc/2045-2322Abstract Esophageal and gastric cancers share some risk factors. This study aimed to compare the long-term trends in mortality rates of esophageal and gastric cancers in China to provide evidence for cancer prevention and control. Mortality data were derived from 103 continuous points of the Disease Surveillance Points system during 1991–2009, stratified by gender and urban-rural locations. Age-period-cohort models were used to disentangle the time trends of esophageal and gastric cancer mortality. The downward slope of the period effect for esophageal cancer was steeper than that for gastric cancer in rural areas. Cohort effect patterns were similar between esophageal and gastric cancers, with an inverse U-shape peaking around the late 1920s and early 1930s. A second peak, appearing around the 1950s, was weaker than the first but apparent in males, especially for esophageal cancer. The more marked changes in period effect for esophageal cancer in rural areas suggest esophageal cancer screening practices are effective in reducing mortality, and similar programs targeting gastric cancer should be implemented. The similarities of the cohort effects in these two cancers support the implication of nutrition deficiency in early childhood in the development of upper gastrointestinal cancer.Mengmeng LiXia WanYanhong WangYuanyuan SunGonghuan YangLi WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mengmeng Li Xia Wan Yanhong Wang Yuanyuan Sun Gonghuan Yang Li Wang Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis
description	Abstract Esophageal and gastric cancers share some risk factors. This study aimed to compare the long-term trends in mortality rates of esophageal and gastric cancers in China to provide evidence for cancer prevention and control. Mortality data were derived from 103 continuous points of the Disease Surveillance Points system during 1991–2009, stratified by gender and urban-rural locations. Age-period-cohort models were used to disentangle the time trends of esophageal and gastric cancer mortality. The downward slope of the period effect for esophageal cancer was steeper than that for gastric cancer in rural areas. Cohort effect patterns were similar between esophageal and gastric cancers, with an inverse U-shape peaking around the late 1920s and early 1930s. A second peak, appearing around the 1950s, was weaker than the first but apparent in males, especially for esophageal cancer. The more marked changes in period effect for esophageal cancer in rural areas suggest esophageal cancer screening practices are effective in reducing mortality, and similar programs targeting gastric cancer should be implemented. The similarities of the cohort effects in these two cancers support the implication of nutrition deficiency in early childhood in the development of upper gastrointestinal cancer.
format	article
author	Mengmeng Li Xia Wan Yanhong Wang Yuanyuan Sun Gonghuan Yang Li Wang
author_facet	Mengmeng Li Xia Wan Yanhong Wang Yuanyuan Sun Gonghuan Yang Li Wang
author_sort	Mengmeng Li
title	Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis
title_short	Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis
title_full	Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis
title_fullStr	Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis
title_full_unstemmed	Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis
title_sort	time trends of esophageal and gastric cancer mortality in china, 1991–2009: an age-period-cohort analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5d3831f2a0104d30811e60004d9e0f4b
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_version_	1718393921522892800

Time trends of esophageal and gastric cancer mortality in China, 1991–2009: an age-period-cohort analysis

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