Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer

Dong Guo,1 Jiafeng Liu,2 Yanping Li,3 Chao Li,3 Quan Liu,3 Shengjun Ji,4 Shuchai Zhu1 1Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Radiotherapy, Rizhao Center Hospital, Rizhao, People’s Republic of China; 3Su...

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Autores principales:	Guo D, Liu J, Li Y, Li C, Liu Q, Ji S, Zhu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	naples prognostic score stage iii nsclc predictive values Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5d38bf196e68456d8aa0c1b7858a3abc
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spelling	oai:doaj.org-article:5d38bf196e68456d8aa0c1b7858a3abc2021-11-23T18:43:01ZEvaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer1178-7031https://doaj.org/article/5d38bf196e68456d8aa0c1b7858a3abc2021-11-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-predictive-values-of-naples-prognostic-score-in-patients-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Dong Guo,1 Jiafeng Liu,2 Yanping Li,3 Chao Li,3 Quan Liu,3 Shengjun Ji,4 Shuchai Zhu1 1Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Radiotherapy, Rizhao Center Hospital, Rizhao, People’s Republic of China; 3Sunshine Union Hospital, Weifang, People’s Republic of China; 4Department of Radiotherapy & Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People’s Republic of ChinaCorrespondence: Shengjun Ji; Shuchai Zhu Email drshengjunji@163.com; 3562069484@qq.comBackground: Naples prognosis score (NPS) is a new prognostic score according to host inflammatory and nutritional state, and it could be useful for predicting tumor prognosis based on albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. This study aimed to evaluate the clinical significance of Naples prognostic score (NPS) in stage III non-small cell lung cancer patients (NSCLC).Patients and Methods: In this study, 206 patients diagnosed with locally advanced NCCLC receiving chemoradiotherapy were retrospectively reviewed from January 2013 to January 2017. The included patients were divided into 3 groups according to NPS (group 0, group 1, and group 2), and the associations of the NPS with clinical characteristics and outcomes were evaluated among the groups. Survival curves for the NPS were analyzed using the Kaplan–Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards regression model to evaluate the prognostic value of overall survival (OS) and progression-free survival (PFS).Results: The median follow-up time of this study was 37.0 (range, 13– 59) months. The median OS was 27 months in group 0, 23 months in group 1, and 21 months in group 2, and median PFS was 15, 12 and 13 in group 0, group 1 and group 2, respectively. Age was significantly different among the 3 groups. The NPS was superior to other host inflammatory and nutritional indexes for prognostic risk stratification. In the multivariate analysis, NPS was identified as an independent prognostic indicator for OS and PFS (all P< 0.05).Conclusion: The NPS system is considered to be a useful predictor of outcomes in patients with stage III NSCLC.Keywords: Naples prognostic score, stage III NSCLC, predictive valuesGuo DLiu JLi YLi CLiu QJi SZhu SDove Medical Pressarticlenaples prognostic scorestage iii nsclcpredictive valuesPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 6129-6141 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	naples prognostic score stage iii nsclc predictive values Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	naples prognostic score stage iii nsclc predictive values Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Guo D Liu J Li Y Li C Liu Q Ji S Zhu S Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
description	Dong Guo,1 Jiafeng Liu,2 Yanping Li,3 Chao Li,3 Quan Liu,3 Shengjun Ji,4 Shuchai Zhu1 1Department of Radiation Oncology, Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Department of Radiotherapy, Rizhao Center Hospital, Rizhao, People’s Republic of China; 3Sunshine Union Hospital, Weifang, People’s Republic of China; 4Department of Radiotherapy & Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, People’s Republic of ChinaCorrespondence: Shengjun Ji; Shuchai Zhu Email drshengjunji@163.com; 3562069484@qq.comBackground: Naples prognosis score (NPS) is a new prognostic score according to host inflammatory and nutritional state, and it could be useful for predicting tumor prognosis based on albumin level, total cholesterol level, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. This study aimed to evaluate the clinical significance of Naples prognostic score (NPS) in stage III non-small cell lung cancer patients (NSCLC).Patients and Methods: In this study, 206 patients diagnosed with locally advanced NCCLC receiving chemoradiotherapy were retrospectively reviewed from January 2013 to January 2017. The included patients were divided into 3 groups according to NPS (group 0, group 1, and group 2), and the associations of the NPS with clinical characteristics and outcomes were evaluated among the groups. Survival curves for the NPS were analyzed using the Kaplan–Meier method. Univariate and multivariate analyses were performed using the Cox proportional hazards regression model to evaluate the prognostic value of overall survival (OS) and progression-free survival (PFS).Results: The median follow-up time of this study was 37.0 (range, 13– 59) months. The median OS was 27 months in group 0, 23 months in group 1, and 21 months in group 2, and median PFS was 15, 12 and 13 in group 0, group 1 and group 2, respectively. Age was significantly different among the 3 groups. The NPS was superior to other host inflammatory and nutritional indexes for prognostic risk stratification. In the multivariate analysis, NPS was identified as an independent prognostic indicator for OS and PFS (all P< 0.05).Conclusion: The NPS system is considered to be a useful predictor of outcomes in patients with stage III NSCLC.Keywords: Naples prognostic score, stage III NSCLC, predictive values
format	article
author	Guo D Liu J Li Y Li C Liu Q Ji S Zhu S
author_facet	Guo D Liu J Li Y Li C Liu Q Ji S Zhu S
author_sort	Guo D
title	Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
title_short	Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
title_full	Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
title_fullStr	Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
title_full_unstemmed	Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer
title_sort	evaluation of predictive values of naples prognostic score in patients with unresectable stage iii non-small cell lung cancer
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5d38bf196e68456d8aa0c1b7858a3abc
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Evaluation of Predictive Values of Naples Prognostic Score in Patients with Unresectable Stage III Non-Small Cell Lung Cancer

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