microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1

The study aimed to investigate the significant potential role of miR-877-5p in Prostate cancer. The expression levels of miR-877-5p and forkhead box M1 (FOXM1) mRNA were detected by qRT-PCR. The prognostic significance of miR-877-5p in prostate cancer was investigated using Kaplan Meier analysis. Th...

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Autores principales:	Bin Yang, Huifeng Diao, Pu Wang, Fengju Guan, Hechen Liu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	prostate cancer mir-877-5p foxm1 prognosis proliferation migration invasion Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/5d3afc24f7a9479c86f36f06226c0994
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spelling	oai:doaj.org-article:5d3afc24f7a9479c86f36f06226c09942021-11-04T15:51:53ZmicroRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M12165-59792165-598710.1080/21655979.2021.1989969https://doaj.org/article/5d3afc24f7a9479c86f36f06226c09942021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1989969https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987The study aimed to investigate the significant potential role of miR-877-5p in Prostate cancer. The expression levels of miR-877-5p and forkhead box M1 (FOXM1) mRNA were detected by qRT-PCR. The prognostic significance of miR-877-5p in prostate cancer was investigated using Kaplan Meier analysis. Then, Cell Counting Kit-8 (CCK-8) and transwell assay were used to evaluate the effects of miR-877-5p on cell biological functions. The mechanism of miR-877-5p action on prostate cancer cells was investigated by luciferase activity assay with wide-type or mutation. miR-877-5p was lowly expressed both in prostate cancer tissues and cell lines compared with corresponding normal counterparts. Further, miR-877-5p was significantly correlated with Gleason score and TNM stage. Moreover, miR-877-5p may serve as an independent prognostic predictor. In addition, FOXM1 was checked as a direct target gene of miR-877-5p, and miR-877-5p can inhibit the expression of FOXM1 to restrain the growth, migration, and invasion abilities of prostate cancer cells. Taken together, miR-877-5p may act as a suppressor in prostate cancer and reduces cancer cell proliferation, migration and invasion by targeting FOXM1. miR-877-5p may serve as the effective biomarkers and therapeutic target for treating prostate cancer patients.Bin YangHuifeng DiaoPu WangFengju GuanHechen LiuTaylor & Francis Grouparticleprostate cancermir-877-5pfoxm1prognosisproliferationmigrationinvasionBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 9094-9102 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer mir-877-5p foxm1 prognosis proliferation migration invasion Biotechnology TP248.13-248.65
spellingShingle	prostate cancer mir-877-5p foxm1 prognosis proliferation migration invasion Biotechnology TP248.13-248.65 Bin Yang Huifeng Diao Pu Wang Fengju Guan Hechen Liu microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
description	The study aimed to investigate the significant potential role of miR-877-5p in Prostate cancer. The expression levels of miR-877-5p and forkhead box M1 (FOXM1) mRNA were detected by qRT-PCR. The prognostic significance of miR-877-5p in prostate cancer was investigated using Kaplan Meier analysis. Then, Cell Counting Kit-8 (CCK-8) and transwell assay were used to evaluate the effects of miR-877-5p on cell biological functions. The mechanism of miR-877-5p action on prostate cancer cells was investigated by luciferase activity assay with wide-type or mutation. miR-877-5p was lowly expressed both in prostate cancer tissues and cell lines compared with corresponding normal counterparts. Further, miR-877-5p was significantly correlated with Gleason score and TNM stage. Moreover, miR-877-5p may serve as an independent prognostic predictor. In addition, FOXM1 was checked as a direct target gene of miR-877-5p, and miR-877-5p can inhibit the expression of FOXM1 to restrain the growth, migration, and invasion abilities of prostate cancer cells. Taken together, miR-877-5p may act as a suppressor in prostate cancer and reduces cancer cell proliferation, migration and invasion by targeting FOXM1. miR-877-5p may serve as the effective biomarkers and therapeutic target for treating prostate cancer patients.
format	article
author	Bin Yang Huifeng Diao Pu Wang Fengju Guan Hechen Liu
author_facet	Bin Yang Huifeng Diao Pu Wang Fengju Guan Hechen Liu
author_sort	Bin Yang
title	microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
title_short	microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
title_full	microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
title_fullStr	microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
title_full_unstemmed	microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
title_sort	microrna-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box m1
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5d3afc24f7a9479c86f36f06226c0994
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microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1

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