A research agenda for malaria eradication: basic science and enabling technologies.

Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the...

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Autor principal:	malERA Consultative Group on Basic Science and Enabling Technologies
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/5d3c98ea081843e8a7f7fe270c6f93a9
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spelling	oai:doaj.org-article:5d3c98ea081843e8a7f7fe270c6f93a92021-11-18T05:41:56ZA research agenda for malaria eradication: basic science and enabling technologies.1549-12771549-167610.1371/journal.pmed.1000399https://doaj.org/article/5d3c98ea081843e8a7f7fe270c6f93a92011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21311584/?tool=EBIhttps://doaj.org/toc/1549-1277https://doaj.org/toc/1549-1676Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.malERA Consultative Group on Basic Science and Enabling TechnologiesPublic Library of Science (PLoS)articleMedicineRENPLoS Medicine, Vol 8, Iss 1, p e1000399 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R malERA Consultative Group on Basic Science and Enabling Technologies A research agenda for malaria eradication: basic science and enabling technologies.
description	Today's malaria control efforts are limited by our incomplete understanding of the biology of Plasmodium and of the complex relationships between human populations and the multiple species of mosquito and parasite. Research priorities include the development of in vitro culture systems for the complete life cycle of P. falciparum and P. vivax and the development of an appropriate liver culture system to study hepatic stages. In addition, genetic technologies for the manipulation of Plasmodium need to be improved, the entire parasite metabolome needs to be characterized to identify new druggable targets, and improved information systems for monitoring the changes in epidemiology, pathology, and host-parasite-vector interactions as a result of intensified control need to be established to bridge the gap between bench, preclinical, clinical, and population-based sciences.
format	article
author	malERA Consultative Group on Basic Science and Enabling Technologies
author_facet	malERA Consultative Group on Basic Science and Enabling Technologies
author_sort	malERA Consultative Group on Basic Science and Enabling Technologies
title	A research agenda for malaria eradication: basic science and enabling technologies.
title_short	A research agenda for malaria eradication: basic science and enabling technologies.
title_full	A research agenda for malaria eradication: basic science and enabling technologies.
title_fullStr	A research agenda for malaria eradication: basic science and enabling technologies.
title_full_unstemmed	A research agenda for malaria eradication: basic science and enabling technologies.
title_sort	research agenda for malaria eradication: basic science and enabling technologies.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/5d3c98ea081843e8a7f7fe270c6f93a9
work_keys_str_mv	AT maleraconsultativegrouponbasicscienceandenablingtechnologies aresearchagendaformalariaeradicationbasicscienceandenablingtechnologies AT maleraconsultativegrouponbasicscienceandenablingtechnologies researchagendaformalariaeradicationbasicscienceandenablingtechnologies
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A research agenda for malaria eradication: basic science and enabling technologies.

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