Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment

Abstract The contamination of chronic wound with bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) is considered as the major factor interferencing normal wound healing. There still remain great challenges in developing safe and effective wound dressings with wide-spectrum antib...

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Autores principales: Shijia Wang, Xiaoli Liu, Miao Lei, Junjie Sun, Xue Qu, Changsheng Liu
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Lenguaje:EN
Publicado: Springer 2021
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spelling oai:doaj.org-article:5d3d4b163e514ecc9a980412c296fe782021-11-28T12:26:52ZContinuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment10.1007/s10856-021-06619-20957-45301573-4838https://doaj.org/article/5d3d4b163e514ecc9a980412c296fe782021-11-01T00:00:00Zhttps://doi.org/10.1007/s10856-021-06619-2https://doaj.org/toc/0957-4530https://doaj.org/toc/1573-4838Abstract The contamination of chronic wound with bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) is considered as the major factor interferencing normal wound healing. There still remain great challenges in developing safe and effective wound dressings with wide-spectrum antibacterial functions. Alginate hydrogel is a common dressing for wound treatment. Copper is one of the trace elements in human body with inherent antibacterial activity. Traditional methods for preparing a structure-controlled copper-alginate antibacterial matrix are difficult however, due to the fast and uncontrolled gelation between alginate and metal ions. In this work, we report an electrodeposition method for rapid fabrication of copper cross-linked alginate antibacterial films (Cu2+-Alg) with controlled structure and copper content, which is relied on an electrical signal controlled release of copper ions from the reaction of insoluble salt Cu2(OH)2CO3 and the generated protons via water electrolysis on anode. The results prove that the physical structure and chemical composition of the electrodeposited Cu2+-Alg films can be continuously modulated by the imposed charges during electrodeposition. In vitro tests demonstrate the film has Cu2+ content-dependent bactericidal activities. Film’s cytocompatibility is well controlled by the imposed charges for Cu2+-Alg fabrication. The MRSA infected wound model in vivo also indicates that Cu2+-Alg film can effectively eliminate bacterial infection and suppress host inflammatory responses. We believe this study demonstrates a convenient and controllable strategy to fabricate alginate antibacterial dressings with potential applications for infected wound treatment. More broadly, our work reveals electrodeposition is a general and simple platform to design alginate films with versatile functions.Shijia WangXiaoli LiuMiao LeiJunjie SunXue QuChangsheng LiuSpringerarticleMaterials of engineering and construction. Mechanics of materialsTA401-492Medical technologyR855-855.5ENJournal of Materials Science: Materials in Medicine, Vol 32, Iss 12, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Materials of engineering and construction. Mechanics of materials
TA401-492
Medical technology
R855-855.5
spellingShingle Materials of engineering and construction. Mechanics of materials
TA401-492
Medical technology
R855-855.5
Shijia Wang
Xiaoli Liu
Miao Lei
Junjie Sun
Xue Qu
Changsheng Liu
Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
description Abstract The contamination of chronic wound with bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) is considered as the major factor interferencing normal wound healing. There still remain great challenges in developing safe and effective wound dressings with wide-spectrum antibacterial functions. Alginate hydrogel is a common dressing for wound treatment. Copper is one of the trace elements in human body with inherent antibacterial activity. Traditional methods for preparing a structure-controlled copper-alginate antibacterial matrix are difficult however, due to the fast and uncontrolled gelation between alginate and metal ions. In this work, we report an electrodeposition method for rapid fabrication of copper cross-linked alginate antibacterial films (Cu2+-Alg) with controlled structure and copper content, which is relied on an electrical signal controlled release of copper ions from the reaction of insoluble salt Cu2(OH)2CO3 and the generated protons via water electrolysis on anode. The results prove that the physical structure and chemical composition of the electrodeposited Cu2+-Alg films can be continuously modulated by the imposed charges during electrodeposition. In vitro tests demonstrate the film has Cu2+ content-dependent bactericidal activities. Film’s cytocompatibility is well controlled by the imposed charges for Cu2+-Alg fabrication. The MRSA infected wound model in vivo also indicates that Cu2+-Alg film can effectively eliminate bacterial infection and suppress host inflammatory responses. We believe this study demonstrates a convenient and controllable strategy to fabricate alginate antibacterial dressings with potential applications for infected wound treatment. More broadly, our work reveals electrodeposition is a general and simple platform to design alginate films with versatile functions.
format article
author Shijia Wang
Xiaoli Liu
Miao Lei
Junjie Sun
Xue Qu
Changsheng Liu
author_facet Shijia Wang
Xiaoli Liu
Miao Lei
Junjie Sun
Xue Qu
Changsheng Liu
author_sort Shijia Wang
title Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
title_short Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
title_full Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
title_fullStr Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
title_full_unstemmed Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
title_sort continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment
publisher Springer
publishDate 2021
url https://doaj.org/article/5d3d4b163e514ecc9a980412c296fe78
work_keys_str_mv AT shijiawang continuousandcontrollableelectrofabricationofantimicrobialcopperalginatedressingforinfectedwoundstreatment
AT xiaoliliu continuousandcontrollableelectrofabricationofantimicrobialcopperalginatedressingforinfectedwoundstreatment
AT miaolei continuousandcontrollableelectrofabricationofantimicrobialcopperalginatedressingforinfectedwoundstreatment
AT junjiesun continuousandcontrollableelectrofabricationofantimicrobialcopperalginatedressingforinfectedwoundstreatment
AT xuequ continuousandcontrollableelectrofabricationofantimicrobialcopperalginatedressingforinfectedwoundstreatment
AT changshengliu continuousandcontrollableelectrofabricationofantimicrobialcopperalginatedressingforinfectedwoundstreatment
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