In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age

Abstract Beta-2 adrenergic receptor (B2AR) agonists, used as asthma treatments and tocolytics during pregnancy, have recently been reported to be associated with autism in their offspring. However, the particular link between autism and ritodrine, a common type of B2AR agonist used solely as tocolyt...

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Autores principales:	Jungsoo Chae, Geum Joon Cho, Min-Jeong Oh, KeonVin Park, Sung Won Han, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d44e59548554f3d9492e38c5e036a66
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spelling	oai:doaj.org-article:5d44e59548554f3d9492e38c5e036a662021-12-02T15:23:04ZIn utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age10.1038/s41598-020-80904-y2045-2322https://doaj.org/article/5d44e59548554f3d9492e38c5e036a662021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80904-yhttps://doaj.org/toc/2045-2322Abstract Beta-2 adrenergic receptor (B2AR) agonists, used as asthma treatments and tocolytics during pregnancy, have recently been reported to be associated with autism in their offspring. However, the particular link between autism and ritodrine, a common type of B2AR agonist used solely as tocolytics, has never been substantiated with any nationwide database. Thus, we aimed to examine the association between in utero exposure of ritodrine and the risk of autism in their offspring using a national database. This population-based cohort study was conducted by merging the Korea National Health Insurance claims database and National Health Screening Program for Infants and Children database. These databases included all women who had delivered singleton between January 2007 and December 2008 in Korea. Out of the total 770,016 mothers, 30,959 (4.02%) were exposed to ritodrine during pregnancy, and 5583 (0.73%) of their children were identified as having autism, defined until 8 years of age. According to our analysis, the overall cumulative incidence of autism up to 8 years was 1.37% in ritodrine exposure group and 0.70% in ritodrine non-exposure group (p < 0.05, log-rank test). By Cox proportional hazard analysis, use of ritodrine in preterm birth was associated with significantly higher hazard of autism [adjusted hazard ratio: 1.23, 95% CI 1.04–1.47], after adjusting for confounding variables including maternal age, parity, cesarean section, preterm labor, steroid use, birth weight, gender, and preeclampsia. Thus, in utero exposure to ritodrine was associated with an increased risk of autism in their offspring.Jungsoo ChaeGeum Joon ChoMin-Jeong OhKeonVin ParkSung Won HanSuk-Joo ChoiSoo-young OhCheong-Rae RohNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jungsoo Chae Geum Joon Cho Min-Jeong Oh KeonVin Park Sung Won Han Suk-Joo Choi Soo-young Oh Cheong-Rae Roh In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
description	Abstract Beta-2 adrenergic receptor (B2AR) agonists, used as asthma treatments and tocolytics during pregnancy, have recently been reported to be associated with autism in their offspring. However, the particular link between autism and ritodrine, a common type of B2AR agonist used solely as tocolytics, has never been substantiated with any nationwide database. Thus, we aimed to examine the association between in utero exposure of ritodrine and the risk of autism in their offspring using a national database. This population-based cohort study was conducted by merging the Korea National Health Insurance claims database and National Health Screening Program for Infants and Children database. These databases included all women who had delivered singleton between January 2007 and December 2008 in Korea. Out of the total 770,016 mothers, 30,959 (4.02%) were exposed to ritodrine during pregnancy, and 5583 (0.73%) of their children were identified as having autism, defined until 8 years of age. According to our analysis, the overall cumulative incidence of autism up to 8 years was 1.37% in ritodrine exposure group and 0.70% in ritodrine non-exposure group (p < 0.05, log-rank test). By Cox proportional hazard analysis, use of ritodrine in preterm birth was associated with significantly higher hazard of autism [adjusted hazard ratio: 1.23, 95% CI 1.04–1.47], after adjusting for confounding variables including maternal age, parity, cesarean section, preterm labor, steroid use, birth weight, gender, and preeclampsia. Thus, in utero exposure to ritodrine was associated with an increased risk of autism in their offspring.
format	article
author	Jungsoo Chae Geum Joon Cho Min-Jeong Oh KeonVin Park Sung Won Han Suk-Joo Choi Soo-young Oh Cheong-Rae Roh
author_facet	Jungsoo Chae Geum Joon Cho Min-Jeong Oh KeonVin Park Sung Won Han Suk-Joo Choi Soo-young Oh Cheong-Rae Roh
author_sort	Jungsoo Chae
title	In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
title_short	In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
title_full	In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
title_fullStr	In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
title_full_unstemmed	In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
title_sort	in utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d44e59548554f3d9492e38c5e036a66
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In utero exposure to ritodrine during pregnancy and risk of autism in their offspring until 8 years of age

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