Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease

Abstract Substantial variability and severity of dysarthric patterns across Parkinson’s disease (PD) patients may reflect distinct phenotypic differences. We aimed to compare patterns of speech disorder in early-onset PD (EOPD) and late-onset PD (LOPD) in drug-naive patients at early stages of disea...

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Autores principales:	Jan Rusz, Tereza Tykalová, Michal Novotný, Evžen Růžička, Petr Dušek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5d4f12d02d2e4d9296416809007e84c7
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spelling	oai:doaj.org-article:5d4f12d02d2e4d9296416809007e84c72021-11-14T12:27:01ZDistinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease10.1038/s41531-021-00243-12373-8057https://doaj.org/article/5d4f12d02d2e4d9296416809007e84c72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00243-1https://doaj.org/toc/2373-8057Abstract Substantial variability and severity of dysarthric patterns across Parkinson’s disease (PD) patients may reflect distinct phenotypic differences. We aimed to compare patterns of speech disorder in early-onset PD (EOPD) and late-onset PD (LOPD) in drug-naive patients at early stages of disease. Speech samples were acquired from a total of 96 participants, including two subgroups of 24 de-novo PD patients and two subgroups of 24 age- and sex-matched young and old healthy controls. The EOPD group included patients with age at onset below 51 (mean 42.6, standard deviation 6.1) years and LOPD group patients with age at onset above 69 (mean 73.9, standard deviation 3.0) years. Quantitative acoustic vocal assessment of 10 unique speech dimensions related to respiration, phonation, articulation, prosody, and speech timing was performed. Despite similar perceptual dysarthria severity in both PD subgroups, EOPD showed weaker inspirations (p = 0.03), while LOPD was characterized by decreased voice quality (p = 0.02) and imprecise consonant articulation (p = 0.03). In addition, age-independent occurrence of monopitch (p < 0.001), monoloudness (p = 0.008), and articulatory decay (p = 0.04) was observed in both PD subgroups. The worsening of consonant articulation was correlated with the severity of axial gait symptoms (r = 0.38, p = 0.008). Speech abnormalities in EOPD and LOPD share common features but also show phenotype-specific characteristics, likely reflecting the influence of aging on the process of neurodegeneration. The distinct pattern of imprecise consonant articulation can be interpreted as an axial motor symptom of PD.Jan RuszTereza TykalováMichal NovotnýEvžen RůžičkaPetr DušekNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Jan Rusz Tereza Tykalová Michal Novotný Evžen Růžička Petr Dušek Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
description	Abstract Substantial variability and severity of dysarthric patterns across Parkinson’s disease (PD) patients may reflect distinct phenotypic differences. We aimed to compare patterns of speech disorder in early-onset PD (EOPD) and late-onset PD (LOPD) in drug-naive patients at early stages of disease. Speech samples were acquired from a total of 96 participants, including two subgroups of 24 de-novo PD patients and two subgroups of 24 age- and sex-matched young and old healthy controls. The EOPD group included patients with age at onset below 51 (mean 42.6, standard deviation 6.1) years and LOPD group patients with age at onset above 69 (mean 73.9, standard deviation 3.0) years. Quantitative acoustic vocal assessment of 10 unique speech dimensions related to respiration, phonation, articulation, prosody, and speech timing was performed. Despite similar perceptual dysarthria severity in both PD subgroups, EOPD showed weaker inspirations (p = 0.03), while LOPD was characterized by decreased voice quality (p = 0.02) and imprecise consonant articulation (p = 0.03). In addition, age-independent occurrence of monopitch (p < 0.001), monoloudness (p = 0.008), and articulatory decay (p = 0.04) was observed in both PD subgroups. The worsening of consonant articulation was correlated with the severity of axial gait symptoms (r = 0.38, p = 0.008). Speech abnormalities in EOPD and LOPD share common features but also show phenotype-specific characteristics, likely reflecting the influence of aging on the process of neurodegeneration. The distinct pattern of imprecise consonant articulation can be interpreted as an axial motor symptom of PD.
format	article
author	Jan Rusz Tereza Tykalová Michal Novotný Evžen Růžička Petr Dušek
author_facet	Jan Rusz Tereza Tykalová Michal Novotný Evžen Růžička Petr Dušek
author_sort	Jan Rusz
title	Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
title_short	Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
title_full	Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
title_fullStr	Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
title_full_unstemmed	Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease
title_sort	distinct patterns of speech disorder in early-onset and late-onset de-novo parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d4f12d02d2e4d9296416809007e84c7
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Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease

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