The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer

The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total...

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Autores principales: Arkadiusz Zygmunt, Kinga Krawczyk-Rusiecka, Elżbieta Skowrońska-Jóźwiak, Katarzyna Wojciechowska-Durczyńska, Ewa Głowacka, Zbigniew Adamczewski, Andrzej Lewiński
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:5d4f77d22540431abe6dbcb240cd082c2021-11-11T17:33:06ZThe Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer10.3390/jcm102149052077-0383https://doaj.org/article/5d4f77d22540431abe6dbcb240cd082c2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4905https://doaj.org/toc/2077-0383The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total thyroidectomy for differentiated thyroid cancer (DTC), without any signs of disease recurrence, who received L-thyroxine, most at non-suppressive doses. For two consecutive days, the patients were administered a standard dose of 0.9 mg rhTSH, i.m. Concentrations of sclerostin, osteocalcin, β-CrossLaps, PTH, and some other parameters, were measured before and five days after the first rhTSH administration. The greater the increase in TSH concentration (∆TSH), the greater the decrease in: ∆sclerostin (r = −0.672; <i>p</i> < 0.001), ∆β-CrossLaps (r = −0.580; <i>p</i> < 0.001) and ∆osteocalcin (r = −0.405; <i>p</i> = 0.029) levels, were recorded. The degree of TSH increase depended on the baseline PTH (r = 0.651; <i>p</i> < 0.001), age, and creatinine concentrations. rhTSH strongly inhibited bone turnover, thus, TSH—independently of thyroid hormones—exerted a direct protective effect on bone metabolism. Baseline PTH affected the magnitude of TSH increase and the degree of lowering in sclerostin and β-CrossLaps that suggest factors affecting PTH may play a role in the effect of TSH on the bone.Arkadiusz ZygmuntKinga Krawczyk-RusieckaElżbieta Skowrońska-JóźwiakKatarzyna Wojciechowska-DurczyńskaEwa GłowackaZbigniew AdamczewskiAndrzej LewińskiMDPI AGarticlethyrotropinsclerostinparathormonbone turnover markersMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4905, p 4905 (2021)
institution DOAJ
collection DOAJ
language EN
topic thyrotropin
sclerostin
parathormon
bone turnover markers
Medicine
R
spellingShingle thyrotropin
sclerostin
parathormon
bone turnover markers
Medicine
R
Arkadiusz Zygmunt
Kinga Krawczyk-Rusiecka
Elżbieta Skowrońska-Jóźwiak
Katarzyna Wojciechowska-Durczyńska
Ewa Głowacka
Zbigniew Adamczewski
Andrzej Lewiński
The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
description The direct effect of TSH on bone metabolism in vivo is difficult to capture as the changes of its concentrations are followed by respective alterations of thyroid hormone levels. We evaluated the effect of recombinant human TSH (rhTSH) on sclerostin and other bone markers in 29 patients after total thyroidectomy for differentiated thyroid cancer (DTC), without any signs of disease recurrence, who received L-thyroxine, most at non-suppressive doses. For two consecutive days, the patients were administered a standard dose of 0.9 mg rhTSH, i.m. Concentrations of sclerostin, osteocalcin, β-CrossLaps, PTH, and some other parameters, were measured before and five days after the first rhTSH administration. The greater the increase in TSH concentration (∆TSH), the greater the decrease in: ∆sclerostin (r = −0.672; <i>p</i> < 0.001), ∆β-CrossLaps (r = −0.580; <i>p</i> < 0.001) and ∆osteocalcin (r = −0.405; <i>p</i> = 0.029) levels, were recorded. The degree of TSH increase depended on the baseline PTH (r = 0.651; <i>p</i> < 0.001), age, and creatinine concentrations. rhTSH strongly inhibited bone turnover, thus, TSH—independently of thyroid hormones—exerted a direct protective effect on bone metabolism. Baseline PTH affected the magnitude of TSH increase and the degree of lowering in sclerostin and β-CrossLaps that suggest factors affecting PTH may play a role in the effect of TSH on the bone.
format article
author Arkadiusz Zygmunt
Kinga Krawczyk-Rusiecka
Elżbieta Skowrońska-Jóźwiak
Katarzyna Wojciechowska-Durczyńska
Ewa Głowacka
Zbigniew Adamczewski
Andrzej Lewiński
author_facet Arkadiusz Zygmunt
Kinga Krawczyk-Rusiecka
Elżbieta Skowrońska-Jóźwiak
Katarzyna Wojciechowska-Durczyńska
Ewa Głowacka
Zbigniew Adamczewski
Andrzej Lewiński
author_sort Arkadiusz Zygmunt
title The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_short The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_full The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_fullStr The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_full_unstemmed The Effect of Recombinant Human TSH on Sclerostin and Other Selected Bone Markers in Patients after Total Thyroidectomy for Differentiated Thyroid Cancer
title_sort effect of recombinant human tsh on sclerostin and other selected bone markers in patients after total thyroidectomy for differentiated thyroid cancer
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/5d4f77d22540431abe6dbcb240cd082c
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