Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.

<h4>Background</h4>Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk.<h4>Methods</h4>We performed a meta-an...

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Autores principales:	Le Zhuang, Weiyuan Ma, Daxing Cai, Hua Zhong, Qing Sun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d50323bec3e46f9b67e0c5d2aea852e
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spelling	oai:doaj.org-article:5d50323bec3e46f9b67e0c5d2aea852e2021-11-18T08:43:40ZAssociations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.1932-620310.1371/journal.pone.0068827https://doaj.org/article/5d50323bec3e46f9b67e0c5d2aea852e2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24324571/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk.<h4>Methods</h4>We performed a meta-analysis to evaluate the associations between TNF-α polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Science were performed for all publications on the associations between TNF-α polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the associations.<h4>Results</h4>Sixteen case-control studies with a total of 2,253 psoriasis cases and 1,947 controls on TNF-α 308 G/A polymorphism and fourteen studies on TNF-α 238 G/A polymorphism with 2,104 cases and 1,838 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with decreased risk of psoriasis under three genetic comparison models (for A versus G: fixed-effects OR 0.71, 95%CI 0.62-0.82, P < 0.001; for AG versus GG: fixed-effects OR 0.67, 95%CI 0.57-0.78, P < 0.001; for AA/AG versus GG: fixed-effects OR 0.67, 95%CI 0.58-0.78, P < 0.001). In addition, TNF-α 238 G/A polymorphism was associated with increased risk of psoriasis under three genetic models (for A versus G: fixed-effects OR 2.46, 95%CI 2.04-2.96, P < 0.001; for AG versus GG: fixed-effects OR 2.69, 95%CI 2.20-3.28, P < 0.001; for AA/AG versus GG: fixed-effects OR 2.68, 95%CI 2.20-3.26, P < 0.001). Subgroup analysis by ethnicity identified a significant association between TNF-α 308 G/A polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a significant association between TNF-α 238 G/A polymorphism and increased risk of psoriasis in Caucasians.<h4>Conclusions</h4>The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with decreased risk of psoriasis, while TNF-α 238 G/A is associated with increased risk of psoriasis.Le ZhuangWeiyuan MaDaxing CaiHua ZhongQing SunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e68827 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Le Zhuang Weiyuan Ma Daxing Cai Hua Zhong Qing Sun Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
description	<h4>Background</h4>Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk.<h4>Methods</h4>We performed a meta-analysis to evaluate the associations between TNF-α polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Science were performed for all publications on the associations between TNF-α polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the associations.<h4>Results</h4>Sixteen case-control studies with a total of 2,253 psoriasis cases and 1,947 controls on TNF-α 308 G/A polymorphism and fourteen studies on TNF-α 238 G/A polymorphism with 2,104 cases and 1,838 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with decreased risk of psoriasis under three genetic comparison models (for A versus G: fixed-effects OR 0.71, 95%CI 0.62-0.82, P < 0.001; for AG versus GG: fixed-effects OR 0.67, 95%CI 0.57-0.78, P < 0.001; for AA/AG versus GG: fixed-effects OR 0.67, 95%CI 0.58-0.78, P < 0.001). In addition, TNF-α 238 G/A polymorphism was associated with increased risk of psoriasis under three genetic models (for A versus G: fixed-effects OR 2.46, 95%CI 2.04-2.96, P < 0.001; for AG versus GG: fixed-effects OR 2.69, 95%CI 2.20-3.28, P < 0.001; for AA/AG versus GG: fixed-effects OR 2.68, 95%CI 2.20-3.26, P < 0.001). Subgroup analysis by ethnicity identified a significant association between TNF-α 308 G/A polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a significant association between TNF-α 238 G/A polymorphism and increased risk of psoriasis in Caucasians.<h4>Conclusions</h4>The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with decreased risk of psoriasis, while TNF-α 238 G/A is associated with increased risk of psoriasis.
format	article
author	Le Zhuang Weiyuan Ma Daxing Cai Hua Zhong Qing Sun
author_facet	Le Zhuang Weiyuan Ma Daxing Cai Hua Zhong Qing Sun
author_sort	Le Zhuang
title	Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
title_short	Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
title_full	Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
title_fullStr	Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
title_full_unstemmed	Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
title_sort	associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5d50323bec3e46f9b67e0c5d2aea852e
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Associations between tumor necrosis factor-α polymorphisms and risk of psoriasis: a meta-analysis.

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