Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy

Abstract Oxidative stress is a well-accepted etiological mechanism that contributes to neuronal dysfunction. Role of oxidative stress as a mechanism of retinopathy in controlled type 2 diabetic patients was evaluated. Participants were divided into three groups: Group 1 as 30 normal eyes of 15 subje...

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Autores principales:	Rania Fahmy, Nouf M. Almutairi, May N. Al-Muammar, Ramesa Shafi Bhat, Nadine Moubayed, Afaf El-Ansary
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d50eb8e0d5d4d2e86d1cb6d06ea76cc
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spelling	oai:doaj.org-article:5d50eb8e0d5d4d2e86d1cb6d06ea76cc2021-12-02T19:04:19ZControlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy10.1038/s41598-021-96891-72045-2322https://doaj.org/article/5d50eb8e0d5d4d2e86d1cb6d06ea76cc2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96891-7https://doaj.org/toc/2045-2322Abstract Oxidative stress is a well-accepted etiological mechanism that contributes to neuronal dysfunction. Role of oxidative stress as a mechanism of retinopathy in controlled type 2 diabetic patients was evaluated. Participants were divided into three groups: Group 1 as 30 normal eyes of 15 subjects, Group 2 comprised 24 eyes of 12 diabetic patients without retinopathy and Group 3 comprised 23 eyes of 12 diabetic patients with different grades of retinopathy (8 eyes with maculopathy). A complete ophthalmological examination was performed. Oxidative stress markers were measured in blood. Macular thickness was different in all quadrants among all groups and showed a tendency to increase in Group 3 due to diabetic retinopathy with insignificant changes in parapapillary retinal nerve fiber layer thickness although thinning was noted also with retinopathy. Non-significant differences in GST and lipid peroxide levels were observed between the three studied groups, whereas vitamin C and GSH levels were higher in diabetic patients when compared to those in controls. As oxidative stress, hyperglycemia and local inflammation are involved in the pathogenesis of DR, the present study proved that the progressive damage can be retarded in controlled type 2 diabetic patients using different treatment modalities that abated oxidative stress.Rania FahmyNouf M. AlmutairiMay N. Al-MuammarRamesa Shafi BhatNadine MoubayedAfaf El-AnsaryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rania Fahmy Nouf M. Almutairi May N. Al-Muammar Ramesa Shafi Bhat Nadine Moubayed Afaf El-Ansary Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
description	Abstract Oxidative stress is a well-accepted etiological mechanism that contributes to neuronal dysfunction. Role of oxidative stress as a mechanism of retinopathy in controlled type 2 diabetic patients was evaluated. Participants were divided into three groups: Group 1 as 30 normal eyes of 15 subjects, Group 2 comprised 24 eyes of 12 diabetic patients without retinopathy and Group 3 comprised 23 eyes of 12 diabetic patients with different grades of retinopathy (8 eyes with maculopathy). A complete ophthalmological examination was performed. Oxidative stress markers were measured in blood. Macular thickness was different in all quadrants among all groups and showed a tendency to increase in Group 3 due to diabetic retinopathy with insignificant changes in parapapillary retinal nerve fiber layer thickness although thinning was noted also with retinopathy. Non-significant differences in GST and lipid peroxide levels were observed between the three studied groups, whereas vitamin C and GSH levels were higher in diabetic patients when compared to those in controls. As oxidative stress, hyperglycemia and local inflammation are involved in the pathogenesis of DR, the present study proved that the progressive damage can be retarded in controlled type 2 diabetic patients using different treatment modalities that abated oxidative stress.
format	article
author	Rania Fahmy Nouf M. Almutairi May N. Al-Muammar Ramesa Shafi Bhat Nadine Moubayed Afaf El-Ansary
author_facet	Rania Fahmy Nouf M. Almutairi May N. Al-Muammar Ramesa Shafi Bhat Nadine Moubayed Afaf El-Ansary
author_sort	Rania Fahmy
title	Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
title_short	Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
title_full	Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
title_fullStr	Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
title_full_unstemmed	Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
title_sort	controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d50eb8e0d5d4d2e86d1cb6d06ea76cc
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Controlled diabetes amends oxidative stress as mechanism related to severity of diabetic retinopathy

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