Protein pI and Intracellular Localization

The protein isoelectric point (pI) can be calculated from an amino acid sequence using computational analysis in a good agreement with experimental data. Availability of whole-genome sequences empowers comparative studies of proteome-wide pI distributions. It was found that the whole-proteome distri...

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Autores principales:	Alexander A. Tokmakov, Atsushi Kurotani, Ken-Ichi Sato
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	protein pI proteome-wide analysis multimodality subcellular localization local environment Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5d52225822974fdb88907a049327f3d5
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spelling	oai:doaj.org-article:5d52225822974fdb88907a049327f3d52021-12-01T13:51:15ZProtein pI and Intracellular Localization2296-889X10.3389/fmolb.2021.775736https://doaj.org/article/5d52225822974fdb88907a049327f3d52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.775736/fullhttps://doaj.org/toc/2296-889XThe protein isoelectric point (pI) can be calculated from an amino acid sequence using computational analysis in a good agreement with experimental data. Availability of whole-genome sequences empowers comparative studies of proteome-wide pI distributions. It was found that the whole-proteome distributions of protein pI values are multimodal in different species. It was further hypothesized that the observed multimodality is associated with subcellular localization-specific differences in local pI distributions. Here, we overview the multimodality of proteome-wide pI distributions in different organisms focusing on the relationships between protein pI and subcellular localization. We also discuss the probable factors responsible for variation of the intracellular localization-specific pI profiles.Alexander A. TokmakovAtsushi KurotaniKen-Ichi SatoFrontiers Media S.A.articleprotein pIproteome-wide analysismultimodalitysubcellular localizationlocal environmentBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	protein pI proteome-wide analysis multimodality subcellular localization local environment Biology (General) QH301-705.5
spellingShingle	protein pI proteome-wide analysis multimodality subcellular localization local environment Biology (General) QH301-705.5 Alexander A. Tokmakov Atsushi Kurotani Ken-Ichi Sato Protein pI and Intracellular Localization
description	The protein isoelectric point (pI) can be calculated from an amino acid sequence using computational analysis in a good agreement with experimental data. Availability of whole-genome sequences empowers comparative studies of proteome-wide pI distributions. It was found that the whole-proteome distributions of protein pI values are multimodal in different species. It was further hypothesized that the observed multimodality is associated with subcellular localization-specific differences in local pI distributions. Here, we overview the multimodality of proteome-wide pI distributions in different organisms focusing on the relationships between protein pI and subcellular localization. We also discuss the probable factors responsible for variation of the intracellular localization-specific pI profiles.
format	article
author	Alexander A. Tokmakov Atsushi Kurotani Ken-Ichi Sato
author_facet	Alexander A. Tokmakov Atsushi Kurotani Ken-Ichi Sato
author_sort	Alexander A. Tokmakov
title	Protein pI and Intracellular Localization
title_short	Protein pI and Intracellular Localization
title_full	Protein pI and Intracellular Localization
title_fullStr	Protein pI and Intracellular Localization
title_full_unstemmed	Protein pI and Intracellular Localization
title_sort	protein pi and intracellular localization
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d52225822974fdb88907a049327f3d5
work_keys_str_mv	AT alexanderatokmakov proteinpiandintracellularlocalization AT atsushikurotani proteinpiandintracellularlocalization AT kenichisato proteinpiandintracellularlocalization
_version_	1718405059861020672

Protein pI and Intracellular Localization

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