Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.

Anatomical differences in the corpus callosum have been found in various psychiatric disorders, but data on the genetic contributions to these differences have been limited. The current study used morphometric MRI data to assess the heritability of corpus callosum size and the genetic correlations a...

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Autores principales:	Girma Woldehawariat, Pedro E Martinez, Peter Hauser, David M Hoover, Wayne W C Drevets, Francis J McMahon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d55462c3eb042b7a010b43508f2fcfc
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spelling	oai:doaj.org-article:5d55462c3eb042b7a010b43508f2fcfc2021-11-11T08:21:17ZCorpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.1932-620310.1371/journal.pone.0099980https://doaj.org/article/5d55462c3eb042b7a010b43508f2fcfc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24968245/?tool=EBIhttps://doaj.org/toc/1932-6203Anatomical differences in the corpus callosum have been found in various psychiatric disorders, but data on the genetic contributions to these differences have been limited. The current study used morphometric MRI data to assess the heritability of corpus callosum size and the genetic correlations among anatomical sub-regions of the corpus callosum among individuals with and without mood disorders. The corpus callosum (CC) was manually segmented at the mid-sagittal plane in 42 women (healthy, n = 14; major depressive disorder, n = 15; bipolar disorder, n = 13) and their 86 child or adolescent offspring. Four anatomical sub-regions (CC-genu, CC2, CC3 and CC-splenium) and total CC were measured and analyzed. Heritability and genetic correlations were estimated using a variance components method, with adjustment for age, sex, diagnosis, and diagnosis x age, where appropriate. Significant heritability was found for several CC sub-regions (P<0.01), with estimated values ranging from 48% (splenium) to 67% (total CC). There were strong and significant genetic correlations among most sub regions. Correlations between the genu and mid-body, between the genu and total corpus callosum, and between anterior and mid body were all >90%, but no significant genetic correlations were detected between ventral and rostral regions in this sample. Genetic factors play an important role in corpus callosum size among individuals. Distinct genetic factors seem to be involved in caudal and rostral regions, consistent with the divergent functional specialization of these brain areas.Girma WoldehawariatPedro E MartinezPeter HauserDavid M HooverWayne W C DrevetsFrancis J McMahonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99980 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Girma Woldehawariat Pedro E Martinez Peter Hauser David M Hoover Wayne W C Drevets Francis J McMahon Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
description	Anatomical differences in the corpus callosum have been found in various psychiatric disorders, but data on the genetic contributions to these differences have been limited. The current study used morphometric MRI data to assess the heritability of corpus callosum size and the genetic correlations among anatomical sub-regions of the corpus callosum among individuals with and without mood disorders. The corpus callosum (CC) was manually segmented at the mid-sagittal plane in 42 women (healthy, n = 14; major depressive disorder, n = 15; bipolar disorder, n = 13) and their 86 child or adolescent offspring. Four anatomical sub-regions (CC-genu, CC2, CC3 and CC-splenium) and total CC were measured and analyzed. Heritability and genetic correlations were estimated using a variance components method, with adjustment for age, sex, diagnosis, and diagnosis x age, where appropriate. Significant heritability was found for several CC sub-regions (P<0.01), with estimated values ranging from 48% (splenium) to 67% (total CC). There were strong and significant genetic correlations among most sub regions. Correlations between the genu and mid-body, between the genu and total corpus callosum, and between anterior and mid body were all >90%, but no significant genetic correlations were detected between ventral and rostral regions in this sample. Genetic factors play an important role in corpus callosum size among individuals. Distinct genetic factors seem to be involved in caudal and rostral regions, consistent with the divergent functional specialization of these brain areas.
format	article
author	Girma Woldehawariat Pedro E Martinez Peter Hauser David M Hoover Wayne W C Drevets Francis J McMahon
author_facet	Girma Woldehawariat Pedro E Martinez Peter Hauser David M Hoover Wayne W C Drevets Francis J McMahon
author_sort	Girma Woldehawariat
title	Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
title_short	Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
title_full	Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
title_fullStr	Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
title_full_unstemmed	Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
title_sort	corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5d55462c3eb042b7a010b43508f2fcfc
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Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.

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