Haplosaurus computes protein haplotypes for use in precision drug design

Proteoforms arise as protein isoforms or as protein haplotypes, which are the result of genetic variation. Here, the authors develop Haplosaurus, a database that computes protein haplotypes genome-wide from existing genotype data and analyse protein haplotype variability in the 1000 Genomes dataset.

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Autores principales:	William Spooner, William McLaren, Timothy Slidel, Donna K. Finch, Robin Butler, Jamie Campbell, Laura Eghobamien, David Rider, Christine Mione Kiefer, Matthew J. Robinson, Colin Hardman, Fiona Cunningham, Tristan Vaughan, Paul Flicek, Catherine Chaillan Huntington
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d598f4d2b124bdea5925a34db6b2887
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spelling	oai:doaj.org-article:5d598f4d2b124bdea5925a34db6b28872021-12-02T17:33:04ZHaplosaurus computes protein haplotypes for use in precision drug design10.1038/s41467-018-06542-12041-1723https://doaj.org/article/5d598f4d2b124bdea5925a34db6b28872018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06542-1https://doaj.org/toc/2041-1723Proteoforms arise as protein isoforms or as protein haplotypes, which are the result of genetic variation. Here, the authors develop Haplosaurus, a database that computes protein haplotypes genome-wide from existing genotype data and analyse protein haplotype variability in the 1000 Genomes dataset.William SpoonerWilliam McLarenTimothy SlidelDonna K. FinchRobin ButlerJamie CampbellLaura EghobamienDavid RiderChristine Mione KieferMatthew J. RobinsonColin HardmanFiona CunninghamTristan VaughanPaul FlicekCatherine Chaillan HuntingtonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q William Spooner William McLaren Timothy Slidel Donna K. Finch Robin Butler Jamie Campbell Laura Eghobamien David Rider Christine Mione Kiefer Matthew J. Robinson Colin Hardman Fiona Cunningham Tristan Vaughan Paul Flicek Catherine Chaillan Huntington Haplosaurus computes protein haplotypes for use in precision drug design
description	Proteoforms arise as protein isoforms or as protein haplotypes, which are the result of genetic variation. Here, the authors develop Haplosaurus, a database that computes protein haplotypes genome-wide from existing genotype data and analyse protein haplotype variability in the 1000 Genomes dataset.
format	article
author	William Spooner William McLaren Timothy Slidel Donna K. Finch Robin Butler Jamie Campbell Laura Eghobamien David Rider Christine Mione Kiefer Matthew J. Robinson Colin Hardman Fiona Cunningham Tristan Vaughan Paul Flicek Catherine Chaillan Huntington
author_facet	William Spooner William McLaren Timothy Slidel Donna K. Finch Robin Butler Jamie Campbell Laura Eghobamien David Rider Christine Mione Kiefer Matthew J. Robinson Colin Hardman Fiona Cunningham Tristan Vaughan Paul Flicek Catherine Chaillan Huntington
author_sort	William Spooner
title	Haplosaurus computes protein haplotypes for use in precision drug design
title_short	Haplosaurus computes protein haplotypes for use in precision drug design
title_full	Haplosaurus computes protein haplotypes for use in precision drug design
title_fullStr	Haplosaurus computes protein haplotypes for use in precision drug design
title_full_unstemmed	Haplosaurus computes protein haplotypes for use in precision drug design
title_sort	haplosaurus computes protein haplotypes for use in precision drug design
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5d598f4d2b124bdea5925a34db6b2887
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Haplosaurus computes protein haplotypes for use in precision drug design

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