Haplosaurus computes protein haplotypes for use in precision drug design

Haplosaurus computes protein haplotypes for use in precision drug design

Proteoforms arise as protein isoforms or as protein haplotypes, which are the result of genetic variation. Here, the authors develop Haplosaurus, a database that computes protein haplotypes genome-wide from existing genotype data and analyse protein haplotype variability in the 1000 Genomes dataset.

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Bibliographic Details
Main Authors: William Spooner, William McLaren, Timothy Slidel, Donna K. Finch, Robin Butler, Jamie Campbell, Laura Eghobamien, David Rider, Christine Mione Kiefer, Matthew J. Robinson, Colin Hardman, Fiona Cunningham, Tristan Vaughan, Paul Flicek, Catherine Chaillan Huntington
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/5d598f4d2b124bdea5925a34db6b2887
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Internet

https://doaj.org/article/5d598f4d2b124bdea5925a34db6b2887

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