A three-dimensional finite element model of cAMP signals

This paper presents a three-dimensional finite element model for cyclic adenosine monophosphate (cAMP) signaling. Governing equations for the synthesis, diffusion, and degradation of cAMP were numerically implemented using the finite element method. Simulated results were displayed as time course pl...

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Autores principales:	R. Warren, T.C. Rich, S.J. Leavesley, A.-V. Phan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Second messenger signals cAMP intracellular signaling Endothelial cells Pulmonary vasculature Finite element analysis Mechanics of engineering. Applied mechanics TA349-359 Technology T
Acceso en línea:	https://doaj.org/article/5d5a410e063b4461bbae6bbb11d618ec
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spelling	oai:doaj.org-article:5d5a410e063b4461bbae6bbb11d618ec2021-11-18T04:52:01ZA three-dimensional finite element model of cAMP signals2666-359710.1016/j.finmec.2021.100041https://doaj.org/article/5d5a410e063b4461bbae6bbb11d618ec2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666359721000329https://doaj.org/toc/2666-3597This paper presents a three-dimensional finite element model for cyclic adenosine monophosphate (cAMP) signaling. Governing equations for the synthesis, diffusion, and degradation of cAMP were numerically implemented using the finite element method. Simulated results were displayed as time course plots of cAMP concentrations at selected nodes within the discretized geometry. The validity of the finite element model was assessed by comparing simulated results against analytical or other numerical solutions of cAMP concentration distribution for a spherical cellular volume. An endothelial cell was also simulated using its discretized geometry obtained from microscopic cellular cross-sectional images. Simulated solutions using the spherical cellular volume produced near identical cAMP concentration plots to the analytical solutions and were in good agreements with numerical results obtained from VCell, an existing software package for modeling cell biological systems. The validated 3-D finite element model was then employed to simulate the cAMP signaling pathway within a pulmonary microvascular endothelial cell geometry.R. WarrenT.C. RichS.J. LeavesleyA.-V. PhanElsevierarticleSecond messenger signalscAMP intracellular signalingEndothelial cellsPulmonary vasculatureFinite element analysisMechanics of engineering. Applied mechanicsTA349-359TechnologyTENForces in Mechanics, Vol 4, Iss , Pp 100041- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Second messenger signals cAMP intracellular signaling Endothelial cells Pulmonary vasculature Finite element analysis Mechanics of engineering. Applied mechanics TA349-359 Technology T
spellingShingle	Second messenger signals cAMP intracellular signaling Endothelial cells Pulmonary vasculature Finite element analysis Mechanics of engineering. Applied mechanics TA349-359 Technology T R. Warren T.C. Rich S.J. Leavesley A.-V. Phan A three-dimensional finite element model of cAMP signals
description	This paper presents a three-dimensional finite element model for cyclic adenosine monophosphate (cAMP) signaling. Governing equations for the synthesis, diffusion, and degradation of cAMP were numerically implemented using the finite element method. Simulated results were displayed as time course plots of cAMP concentrations at selected nodes within the discretized geometry. The validity of the finite element model was assessed by comparing simulated results against analytical or other numerical solutions of cAMP concentration distribution for a spherical cellular volume. An endothelial cell was also simulated using its discretized geometry obtained from microscopic cellular cross-sectional images. Simulated solutions using the spherical cellular volume produced near identical cAMP concentration plots to the analytical solutions and were in good agreements with numerical results obtained from VCell, an existing software package for modeling cell biological systems. The validated 3-D finite element model was then employed to simulate the cAMP signaling pathway within a pulmonary microvascular endothelial cell geometry.
format	article
author	R. Warren T.C. Rich S.J. Leavesley A.-V. Phan
author_facet	R. Warren T.C. Rich S.J. Leavesley A.-V. Phan
author_sort	R. Warren
title	A three-dimensional finite element model of cAMP signals
title_short	A three-dimensional finite element model of cAMP signals
title_full	A three-dimensional finite element model of cAMP signals
title_fullStr	A three-dimensional finite element model of cAMP signals
title_full_unstemmed	A three-dimensional finite element model of cAMP signals
title_sort	three-dimensional finite element model of camp signals
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5d5a410e063b4461bbae6bbb11d618ec
work_keys_str_mv	AT rwarren athreedimensionalfiniteelementmodelofcampsignals AT tcrich athreedimensionalfiniteelementmodelofcampsignals AT sjleavesley athreedimensionalfiniteelementmodelofcampsignals AT avphan athreedimensionalfiniteelementmodelofcampsignals AT rwarren threedimensionalfiniteelementmodelofcampsignals AT tcrich threedimensionalfiniteelementmodelofcampsignals AT sjleavesley threedimensionalfiniteelementmodelofcampsignals AT avphan threedimensionalfiniteelementmodelofcampsignals
_version_	1718424975209136128

A three-dimensional finite element model of cAMP signals

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