Myonuclear content regulates cell size with similar scaling properties in mice and humans

Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.

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Detalles Bibliográficos
Autores principales: Kenth-Arne Hansson, Einar Eftestøl, Jo C. Bruusgaard, Inga Juvkam, Alyssa W. Cramer, Anders Malthe-Sørenssen, Douglas P. Millay, Kristian Gundersen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/5d5adb3056ce4ec69fb5ac2c1d9dd836
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Sumario:Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.