Myonuclear content regulates cell size with similar scaling properties in mice and humans

Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.

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Autores principales:	Kenth-Arne Hansson, Einar Eftestøl, Jo C. Bruusgaard, Inga Juvkam, Alyssa W. Cramer, Anders Malthe-Sørenssen, Douglas P. Millay, Kristian Gundersen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d5adb3056ce4ec69fb5ac2c1d9dd836
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spelling	oai:doaj.org-article:5d5adb3056ce4ec69fb5ac2c1d9dd8362021-12-02T14:16:40ZMyonuclear content regulates cell size with similar scaling properties in mice and humans10.1038/s41467-020-20057-82041-1723https://doaj.org/article/5d5adb3056ce4ec69fb5ac2c1d9dd8362020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20057-8https://doaj.org/toc/2041-1723Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.Kenth-Arne HanssonEinar EftestølJo C. BruusgaardInga JuvkamAlyssa W. CramerAnders Malthe-SørenssenDouglas P. MillayKristian GundersenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenth-Arne Hansson Einar Eftestøl Jo C. Bruusgaard Inga Juvkam Alyssa W. Cramer Anders Malthe-Sørenssen Douglas P. Millay Kristian Gundersen Myonuclear content regulates cell size with similar scaling properties in mice and humans
description	Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.
format	article
author	Kenth-Arne Hansson Einar Eftestøl Jo C. Bruusgaard Inga Juvkam Alyssa W. Cramer Anders Malthe-Sørenssen Douglas P. Millay Kristian Gundersen
author_facet	Kenth-Arne Hansson Einar Eftestøl Jo C. Bruusgaard Inga Juvkam Alyssa W. Cramer Anders Malthe-Sørenssen Douglas P. Millay Kristian Gundersen
author_sort	Kenth-Arne Hansson
title	Myonuclear content regulates cell size with similar scaling properties in mice and humans
title_short	Myonuclear content regulates cell size with similar scaling properties in mice and humans
title_full	Myonuclear content regulates cell size with similar scaling properties in mice and humans
title_fullStr	Myonuclear content regulates cell size with similar scaling properties in mice and humans
title_full_unstemmed	Myonuclear content regulates cell size with similar scaling properties in mice and humans
title_sort	myonuclear content regulates cell size with similar scaling properties in mice and humans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5d5adb3056ce4ec69fb5ac2c1d9dd836
work_keys_str_mv	AT kentharnehansson myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT einareftestøl myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT jocbruusgaard myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT ingajuvkam myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT alyssawcramer myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT andersmalthesørenssen myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT douglaspmillay myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans AT kristiangundersen myonuclearcontentregulatescellsizewithsimilarscalingpropertiesinmiceandhumans
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Myonuclear content regulates cell size with similar scaling properties in mice and humans

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