Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA

Retinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of...

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Auteurs principaux:	Luis Mendes, Inês P. Marques, José Cunha-Vaz
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	OCTA diabetes retinopathy vascular retina Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Accès en ligne:	https://doaj.org/article/5d5c569c5a5743849b3e538c7caae31d
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spelling	oai:doaj.org-article:5d5c569c5a5743849b3e538c7caae31d2021-12-01T20:30:42ZComparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA1662-453X10.3389/fnins.2021.755730https://doaj.org/article/5d5c569c5a5743849b3e538c7caae31d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.755730/fullhttps://doaj.org/toc/1662-453XRetinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of 11 different metrics, which include 2 metrics supplied by the manufacturer, based on OCTA for identification of VC in different Early Treatment for Diabetic Retinopathy Study (ETDRS) severity groups. OCTA en-face slabs from 84 healthy eyes (70 ± 4.8 years) and 78 eyes of diabetic individuals (67 ± 7.5 years) were processed using different methods that include abnormal intercapillary spaces (AIS), vessel density (VD), and nine metrics extracted from the en-face slab. The best separation between the eyes with DR and the control group was obtained in the superficial capillary plexus (SCP), with the full retina (FR) also performing well. In the SCP, the metrics that show better performance were the AIS and the VD with a value of area under curve (AUC) equal to 0.89 [95% CI 0.84–0.94] and 0.85 [95% CI 0.79–0.91], respectively, indicating that the VD metric supported by the manufacturer is satisfactory. The values of these metrics on the different ETDRS groups show a progressive increase in VC, which is correlated with disease severity.Luis MendesInês P. MarquesInês P. MarquesJosé Cunha-VazJosé Cunha-VazFrontiers Media S.A.articleOCTAdiabetesretinopathyvascularretinaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	OCTA diabetes retinopathy vascular retina Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	OCTA diabetes retinopathy vascular retina Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Luis Mendes Inês P. Marques Inês P. Marques José Cunha-Vaz José Cunha-Vaz Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
description	Retinal vessel metrics identifying microvascular changes such as vessel closure (VC) have shown potential clinical value by identifying eyes with diabetic retinopathy (DR) at different severity levels and at increased risk for disease progression to more severe stages. We compare the performance of 11 different metrics, which include 2 metrics supplied by the manufacturer, based on OCTA for identification of VC in different Early Treatment for Diabetic Retinopathy Study (ETDRS) severity groups. OCTA en-face slabs from 84 healthy eyes (70 ± 4.8 years) and 78 eyes of diabetic individuals (67 ± 7.5 years) were processed using different methods that include abnormal intercapillary spaces (AIS), vessel density (VD), and nine metrics extracted from the en-face slab. The best separation between the eyes with DR and the control group was obtained in the superficial capillary plexus (SCP), with the full retina (FR) also performing well. In the SCP, the metrics that show better performance were the AIS and the VD with a value of area under curve (AUC) equal to 0.89 [95% CI 0.84–0.94] and 0.85 [95% CI 0.79–0.91], respectively, indicating that the VD metric supported by the manufacturer is satisfactory. The values of these metrics on the different ETDRS groups show a progressive increase in VC, which is correlated with disease severity.
format	article
author	Luis Mendes Inês P. Marques Inês P. Marques José Cunha-Vaz José Cunha-Vaz
author_facet	Luis Mendes Inês P. Marques Inês P. Marques José Cunha-Vaz José Cunha-Vaz
author_sort	Luis Mendes
title	Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
title_short	Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
title_full	Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
title_fullStr	Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
title_full_unstemmed	Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA
title_sort	comparison of different metrics for the identification of vascular changes in diabetic retinopathy using octa
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d5c569c5a5743849b3e538c7caae31d
work_keys_str_mv	AT luismendes comparisonofdifferentmetricsfortheidentificationofvascularchangesindiabeticretinopathyusingocta AT inespmarques comparisonofdifferentmetricsfortheidentificationofvascularchangesindiabeticretinopathyusingocta AT inespmarques comparisonofdifferentmetricsfortheidentificationofvascularchangesindiabeticretinopathyusingocta AT josecunhavaz comparisonofdifferentmetricsfortheidentificationofvascularchangesindiabeticretinopathyusingocta AT josecunhavaz comparisonofdifferentmetricsfortheidentificationofvascularchangesindiabeticretinopathyusingocta
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Comparison of Different Metrics for the Identification of Vascular Changes in Diabetic Retinopathy Using OCTA

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