DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift

Julia Franzen et al. investigate if changes in DNA methylation at specific genetic loci during cell culture expansion are due to a specific mechanism or gradual deregulation of an epigenetic state. Their results suggest that changes in CpG methylation are due to indirect epigenetic drift, rather tha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Julia Franzen, Theodoros Georgomanolis, Anton Selich, Chao-Chung Kuo, Reinhard Stöger, Lilija Brant, Melita Sara Mulabdić, Eduardo Fernandez-Rebollo, Clara Grezella, Alina Ostrowska, Matthias Begemann, Miloš Nikolić, Björn Rath, Anthony D. Ho, Michael Rothe, Axel Schambach, Argyris Papantonis, Wolfgang Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5d5f8f022ec24a2b9fe369de12508d55
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d5f8f022ec24a2b9fe369de12508d55
record_format	dspace
spelling	oai:doaj.org-article:5d5f8f022ec24a2b9fe369de12508d552021-12-02T15:52:47ZDNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift10.1038/s42003-021-02116-y2399-3642https://doaj.org/article/5d5f8f022ec24a2b9fe369de12508d552021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02116-yhttps://doaj.org/toc/2399-3642Julia Franzen et al. investigate if changes in DNA methylation at specific genetic loci during cell culture expansion are due to a specific mechanism or gradual deregulation of an epigenetic state. Their results suggest that changes in CpG methylation are due to indirect epigenetic drift, rather than a consequence of targeting by DNA methyltransferases.Julia FranzenTheodoros GeorgomanolisAnton SelichChao-Chung KuoReinhard StögerLilija BrantMelita Sara MulabdićEduardo Fernandez-RebolloClara GrezellaAlina OstrowskaMatthias BegemannMiloš NikolićBjörn RathAnthony D. HoMichael RotheAxel SchambachArgyris PapantonisWolfgang WagnerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Julia Franzen Theodoros Georgomanolis Anton Selich Chao-Chung Kuo Reinhard Stöger Lilija Brant Melita Sara Mulabdić Eduardo Fernandez-Rebollo Clara Grezella Alina Ostrowska Matthias Begemann Miloš Nikolić Björn Rath Anthony D. Ho Michael Rothe Axel Schambach Argyris Papantonis Wolfgang Wagner DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
description	Julia Franzen et al. investigate if changes in DNA methylation at specific genetic loci during cell culture expansion are due to a specific mechanism or gradual deregulation of an epigenetic state. Their results suggest that changes in CpG methylation are due to indirect epigenetic drift, rather than a consequence of targeting by DNA methyltransferases.
format	article
author	Julia Franzen Theodoros Georgomanolis Anton Selich Chao-Chung Kuo Reinhard Stöger Lilija Brant Melita Sara Mulabdić Eduardo Fernandez-Rebollo Clara Grezella Alina Ostrowska Matthias Begemann Miloš Nikolić Björn Rath Anthony D. Ho Michael Rothe Axel Schambach Argyris Papantonis Wolfgang Wagner
author_facet	Julia Franzen Theodoros Georgomanolis Anton Selich Chao-Chung Kuo Reinhard Stöger Lilija Brant Melita Sara Mulabdić Eduardo Fernandez-Rebollo Clara Grezella Alina Ostrowska Matthias Begemann Miloš Nikolić Björn Rath Anthony D. Ho Michael Rothe Axel Schambach Argyris Papantonis Wolfgang Wagner
author_sort	Julia Franzen
title	DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
title_short	DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
title_full	DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
title_fullStr	DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
title_full_unstemmed	DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift
title_sort	dna methylation changes during long-term in vitro cell culture are caused by epigenetic drift
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5d5f8f022ec24a2b9fe369de12508d55
work_keys_str_mv	AT juliafranzen dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT theodorosgeorgomanolis dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT antonselich dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT chaochungkuo dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT reinhardstoger dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT lilijabrant dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT melitasaramulabdic dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT eduardofernandezrebollo dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT claragrezella dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT alinaostrowska dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT matthiasbegemann dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT milosnikolic dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT bjornrath dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT anthonydho dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT michaelrothe dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT axelschambach dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT argyrispapantonis dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift AT wolfgangwagner dnamethylationchangesduringlongterminvitrocellculturearecausedbyepigeneticdrift
_version_	1718385573263048704

DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift

Ejemplares similares