The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.

Interactions between individual members of the B-cell lymphoma 2 (Bcl-2) family of proteins form a regulatory network governing mitochondrial outer membrane permeabilization (MOMP). Bcl-2 family initiated MOMP causes release of the inter-membrane pro-apoptotic proteins to cytosol and creates a cytos...

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Autores principales:	Tomas Tokar, Jozef Ulicny
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d607f25d7fd48b384bc9945965ba315
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spelling	oai:doaj.org-article:5d607f25d7fd48b384bc9945965ba3152021-11-18T08:40:26ZThe mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.1932-620310.1371/journal.pone.0081861https://doaj.org/article/5d607f25d7fd48b384bc9945965ba3152013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386084/?tool=EBIhttps://doaj.org/toc/1932-6203Interactions between individual members of the B-cell lymphoma 2 (Bcl-2) family of proteins form a regulatory network governing mitochondrial outer membrane permeabilization (MOMP). Bcl-2 family initiated MOMP causes release of the inter-membrane pro-apoptotic proteins to cytosol and creates a cytosolic environment suitable for the executionary phase of apoptosis. We designed the mathematical model of this regulatory network where the synthesis rates of the Bcl-2 family members served as the independent inputs. Using computational simulations, we have then analyzed the response of the model to up-/downregulation of the Bcl-2 proteins. Under several assumptions, and using estimated reaction parameters, a non-linear stimulus-response emerged, whose characteristics are associated with bistability and switch-like behavior. Interestingly, using the principal component analysis (PCA) we have shown that the given model of the Bcl-2 family interactions classifies the random combinations of inputs into two distinct classes, and responds to these by one of the two qualitatively distinct outputs. As we showed, the emergence of this behavior requires specific organization of the interactions between particular Bcl-2 proteins.Tomas TokarJozef UlicnyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e81861 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomas Tokar Jozef Ulicny The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.
description	Interactions between individual members of the B-cell lymphoma 2 (Bcl-2) family of proteins form a regulatory network governing mitochondrial outer membrane permeabilization (MOMP). Bcl-2 family initiated MOMP causes release of the inter-membrane pro-apoptotic proteins to cytosol and creates a cytosolic environment suitable for the executionary phase of apoptosis. We designed the mathematical model of this regulatory network where the synthesis rates of the Bcl-2 family members served as the independent inputs. Using computational simulations, we have then analyzed the response of the model to up-/downregulation of the Bcl-2 proteins. Under several assumptions, and using estimated reaction parameters, a non-linear stimulus-response emerged, whose characteristics are associated with bistability and switch-like behavior. Interestingly, using the principal component analysis (PCA) we have shown that the given model of the Bcl-2 family interactions classifies the random combinations of inputs into two distinct classes, and responds to these by one of the two qualitatively distinct outputs. As we showed, the emergence of this behavior requires specific organization of the interactions between particular Bcl-2 proteins.
format	article
author	Tomas Tokar Jozef Ulicny
author_facet	Tomas Tokar Jozef Ulicny
author_sort	Tomas Tokar
title	The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.
title_short	The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.
title_full	The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.
title_fullStr	The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.
title_full_unstemmed	The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.
title_sort	mathematical model of the bcl-2 family mediated momp regulation can perform a non-trivial pattern recognition.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5d607f25d7fd48b384bc9945965ba315
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The mathematical model of the Bcl-2 family mediated MOMP regulation can perform a non-trivial pattern recognition.

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