UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

The U-box ubiquitin ligase UFD-2 is one of the most abundant components of the ubiquitin proteasome system in muscle cells. Here the authors perform in vitro and in vivo experiments and show that UFD-2 has E3 ligase activity and that it ubiquitinates unfolded myosin using the C. elegans myosin chape...

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Autores principales:	Doris Hellerschmied, Max Roessler, Anita Lehner, Linn Gazda, Karel Stejskal, Richard Imre, Karl Mechtler, Alexander Dammermann, Tim Clausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d615670363d4e18b6f7439c5d092bfd
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spelling	oai:doaj.org-article:5d615670363d4e18b6f7439c5d092bfd2021-12-02T15:33:37ZUFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins10.1038/s41467-018-02924-72041-1723https://doaj.org/article/5d615670363d4e18b6f7439c5d092bfd2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02924-7https://doaj.org/toc/2041-1723The U-box ubiquitin ligase UFD-2 is one of the most abundant components of the ubiquitin proteasome system in muscle cells. Here the authors perform in vitro and in vivo experiments and show that UFD-2 has E3 ligase activity and that it ubiquitinates unfolded myosin using the C. elegans myosin chaperone UNC-45 as an adaptor protein.Doris HellerschmiedMax RoesslerAnita LehnerLinn GazdaKarel StejskalRichard ImreKarl MechtlerAlexander DammermannTim ClausenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Doris Hellerschmied Max Roessler Anita Lehner Linn Gazda Karel Stejskal Richard Imre Karl Mechtler Alexander Dammermann Tim Clausen UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
description	The U-box ubiquitin ligase UFD-2 is one of the most abundant components of the ubiquitin proteasome system in muscle cells. Here the authors perform in vitro and in vivo experiments and show that UFD-2 has E3 ligase activity and that it ubiquitinates unfolded myosin using the C. elegans myosin chaperone UNC-45 as an adaptor protein.
format	article
author	Doris Hellerschmied Max Roessler Anita Lehner Linn Gazda Karel Stejskal Richard Imre Karl Mechtler Alexander Dammermann Tim Clausen
author_facet	Doris Hellerschmied Max Roessler Anita Lehner Linn Gazda Karel Stejskal Richard Imre Karl Mechtler Alexander Dammermann Tim Clausen
author_sort	Doris Hellerschmied
title	UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
title_short	UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
title_full	UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
title_fullStr	UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
title_full_unstemmed	UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins
title_sort	ufd-2 is an adaptor-assisted e3 ligase targeting unfolded proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5d615670363d4e18b6f7439c5d092bfd
work_keys_str_mv	AT dorishellerschmied ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT maxroessler ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT anitalehner ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT linngazda ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT karelstejskal ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT richardimre ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT karlmechtler ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT alexanderdammermann ufd2isanadaptorassistede3ligasetargetingunfoldedproteins AT timclausen ufd2isanadaptorassistede3ligasetargetingunfoldedproteins
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UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins

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