PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

Signalling pathways that mediate macrophage activation in disease are poorly understood. Here the authors show that inhibition of PARP9 and/or activation of PARP14 may attenuate macrophage-mediated vascular diseases, and also provide new insight into the development of effective therapies for other...

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Autores principales:	Hiroshi Iwata, Claudia Goettsch, Amitabh Sharma, Piero Ricchiuto, Wilson Wen Bin Goh, Arda Halu, Iwao Yamada, Hideo Yoshida, Takuya Hara, Mei Wei, Noriyuki Inoue, Daiju Fukuda, Alexander Mojcher, Peter C. Mattson, Albert-László Barabási, Mark Boothby, Elena Aikawa, Sasha A. Singh, Masanori Aikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d6435ff7410464bbef7e214ba9acd61
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spelling	oai:doaj.org-article:5d6435ff7410464bbef7e214ba9acd612021-12-02T17:31:50ZPARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation10.1038/ncomms128492041-1723https://doaj.org/article/5d6435ff7410464bbef7e214ba9acd612016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12849https://doaj.org/toc/2041-1723Signalling pathways that mediate macrophage activation in disease are poorly understood. Here the authors show that inhibition of PARP9 and/or activation of PARP14 may attenuate macrophage-mediated vascular diseases, and also provide new insight into the development of effective therapies for other inflammatory disorders.Hiroshi IwataClaudia GoettschAmitabh SharmaPiero RicchiutoWilson Wen Bin GohArda HaluIwao YamadaHideo YoshidaTakuya HaraMei WeiNoriyuki InoueDaiju FukudaAlexander MojcherPeter C. MattsonAlbert-László BarabásiMark BoothbyElena AikawaSasha A. SinghMasanori AikawaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroshi Iwata Claudia Goettsch Amitabh Sharma Piero Ricchiuto Wilson Wen Bin Goh Arda Halu Iwao Yamada Hideo Yoshida Takuya Hara Mei Wei Noriyuki Inoue Daiju Fukuda Alexander Mojcher Peter C. Mattson Albert-László Barabási Mark Boothby Elena Aikawa Sasha A. Singh Masanori Aikawa PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
description	Signalling pathways that mediate macrophage activation in disease are poorly understood. Here the authors show that inhibition of PARP9 and/or activation of PARP14 may attenuate macrophage-mediated vascular diseases, and also provide new insight into the development of effective therapies for other inflammatory disorders.
format	article
author	Hiroshi Iwata Claudia Goettsch Amitabh Sharma Piero Ricchiuto Wilson Wen Bin Goh Arda Halu Iwao Yamada Hideo Yoshida Takuya Hara Mei Wei Noriyuki Inoue Daiju Fukuda Alexander Mojcher Peter C. Mattson Albert-László Barabási Mark Boothby Elena Aikawa Sasha A. Singh Masanori Aikawa
author_facet	Hiroshi Iwata Claudia Goettsch Amitabh Sharma Piero Ricchiuto Wilson Wen Bin Goh Arda Halu Iwao Yamada Hideo Yoshida Takuya Hara Mei Wei Noriyuki Inoue Daiju Fukuda Alexander Mojcher Peter C. Mattson Albert-László Barabási Mark Boothby Elena Aikawa Sasha A. Singh Masanori Aikawa
author_sort	Hiroshi Iwata
title	PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
title_short	PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
title_full	PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
title_fullStr	PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
title_full_unstemmed	PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
title_sort	parp9 and parp14 cross-regulate macrophage activation via stat1 adp-ribosylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5d6435ff7410464bbef7e214ba9acd61
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PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

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