PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation

Signalling pathways that mediate macrophage activation in disease are poorly understood. Here the authors show that inhibition of PARP9 and/or activation of PARP14 may attenuate macrophage-mediated vascular diseases, and also provide new insight into the development of effective therapies for other...

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Main Authors: Hiroshi Iwata, Claudia Goettsch, Amitabh Sharma, Piero Ricchiuto, Wilson Wen Bin Goh, Arda Halu, Iwao Yamada, Hideo Yoshida, Takuya Hara, Mei Wei, Noriyuki Inoue, Daiju Fukuda, Alexander Mojcher, Peter C. Mattson, Albert-László Barabási, Mark Boothby, Elena Aikawa, Sasha A. Singh, Masanori Aikawa
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/5d6435ff7410464bbef7e214ba9acd61
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https://doaj.org/article/5d6435ff7410464bbef7e214ba9acd61

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