The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition

Abstract Background Cardiometabolic (CM) risk affects approximately 25% of adults globally, and is diagnosed by meeting 3 out of 5 of the following CM risk factors: elevated blood pressure, high triglycerides, elevated blood sugar, low high-density lipoprotein (HDL) level, and abdominal obesity. Adu...

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Autores principales:	Danny Baghdan, Lara R. Dugas, Candice Choo-Kang, Jacob Plange-Rhule, Pascal Bovet, Bharathi Viswanathan, Terrence Forrester, Estelle V. Lambert, Walter Riesen, Wolfgang Korte, Mashkoor A. Choudhry, Amy Luke
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	African-origin populations Cardiometabolic risk Alcohol consumption And Epidemiologic transition Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/5d663d2cd1294cfb8bb0d8a1ff58194b
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spelling	oai:doaj.org-article:5d663d2cd1294cfb8bb0d8a1ff58194b2021-12-05T12:09:25ZThe associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition10.1186/s12889-021-12128-21471-2458https://doaj.org/article/5d663d2cd1294cfb8bb0d8a1ff58194b2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12889-021-12128-2https://doaj.org/toc/1471-2458Abstract Background Cardiometabolic (CM) risk affects approximately 25% of adults globally, and is diagnosed by meeting 3 out of 5 of the following CM risk factors: elevated blood pressure, high triglycerides, elevated blood sugar, low high-density lipoprotein (HDL) level, and abdominal obesity. Adults with CM risk are approximately 22% more likely to have higher mortality rates, and alcohol consumption may be associated with higher CM risk. While previous studies have investigated this potential connection, the majority of them did not include African-origin adults. Therefore, the study aimed to explore the association between alcohol intake and CM risk in 5 African-origin cohorts, spanning the epidemiologic transition in Ghana, South Africa, Jamaica, Seychelles and the United States of America. Methods Measurements included clinical measures for CM risk and self-reported alcohol consumption. Each participant was categorized into one of three drinking categories: non-drinker, light drinker (1–3 drinks daily for men and 1–2 drinks daily for women) and heavy drinker (4 or more drinks every day for men and 3 or more drinks per day for women). Using non-drinker status as the reference, the association between alcohol consumption status and prevalence of each of the five CM risk factors and overall elevated CM risk (having 3 out of 5 risk factors) was explored, adjusting for site, age and sex. Associations were explored using logistic regression and significance was determined using odds ratios (OR) and 95% confidence intervals. Results Neither light nor heavy drinking was associated with increased odds for having higher CM risk compared to nondrinkers (OR = 1.05, p = 0.792 and OR = 1.11, p = 0.489, respectively). However, light drinking was associated with lower odds for having low high density lipoproteins (HDL) cholesterol (OR = 0.69, p = 0.002) and increased risk for high triglycerides (OR = 1.48, p = 0.030). Heavy drinking was associated with elevated blood pressure (OR = 1.59, p = 0.002), high triglycerides (OR = 1.73, p = 0.006) and decreased risk of low HDL-cholesterol (OR = 0.621, p < 0.0005). Finally, country-specific analyses indicated that the relationship between heavy drinking and elevated CM risk varied widely across sites. Conclusion While several CM risk factors were associated with alcohol consumption, the associations were inconsistent and varied widely across five international cohorts of African-origin. Future studies should focus on understanding the individual site-related effects.Danny BaghdanLara R. DugasCandice Choo-KangJacob Plange-RhulePascal BovetBharathi ViswanathanTerrence ForresterEstelle V. LambertWalter RiesenWolfgang KorteMashkoor A. ChoudhryAmy LukeBMCarticleAfrican-origin populationsCardiometabolic riskAlcohol consumptionAnd Epidemiologic transitionPublic aspects of medicineRA1-1270ENBMC Public Health, Vol 21, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	African-origin populations Cardiometabolic risk Alcohol consumption And Epidemiologic transition Public aspects of medicine RA1-1270
spellingShingle	African-origin populations Cardiometabolic risk Alcohol consumption And Epidemiologic transition Public aspects of medicine RA1-1270 Danny Baghdan Lara R. Dugas Candice Choo-Kang Jacob Plange-Rhule Pascal Bovet Bharathi Viswanathan Terrence Forrester Estelle V. Lambert Walter Riesen Wolfgang Korte Mashkoor A. Choudhry Amy Luke The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition
description	Abstract Background Cardiometabolic (CM) risk affects approximately 25% of adults globally, and is diagnosed by meeting 3 out of 5 of the following CM risk factors: elevated blood pressure, high triglycerides, elevated blood sugar, low high-density lipoprotein (HDL) level, and abdominal obesity. Adults with CM risk are approximately 22% more likely to have higher mortality rates, and alcohol consumption may be associated with higher CM risk. While previous studies have investigated this potential connection, the majority of them did not include African-origin adults. Therefore, the study aimed to explore the association between alcohol intake and CM risk in 5 African-origin cohorts, spanning the epidemiologic transition in Ghana, South Africa, Jamaica, Seychelles and the United States of America. Methods Measurements included clinical measures for CM risk and self-reported alcohol consumption. Each participant was categorized into one of three drinking categories: non-drinker, light drinker (1–3 drinks daily for men and 1–2 drinks daily for women) and heavy drinker (4 or more drinks every day for men and 3 or more drinks per day for women). Using non-drinker status as the reference, the association between alcohol consumption status and prevalence of each of the five CM risk factors and overall elevated CM risk (having 3 out of 5 risk factors) was explored, adjusting for site, age and sex. Associations were explored using logistic regression and significance was determined using odds ratios (OR) and 95% confidence intervals. Results Neither light nor heavy drinking was associated with increased odds for having higher CM risk compared to nondrinkers (OR = 1.05, p = 0.792 and OR = 1.11, p = 0.489, respectively). However, light drinking was associated with lower odds for having low high density lipoproteins (HDL) cholesterol (OR = 0.69, p = 0.002) and increased risk for high triglycerides (OR = 1.48, p = 0.030). Heavy drinking was associated with elevated blood pressure (OR = 1.59, p = 0.002), high triglycerides (OR = 1.73, p = 0.006) and decreased risk of low HDL-cholesterol (OR = 0.621, p < 0.0005). Finally, country-specific analyses indicated that the relationship between heavy drinking and elevated CM risk varied widely across sites. Conclusion While several CM risk factors were associated with alcohol consumption, the associations were inconsistent and varied widely across five international cohorts of African-origin. Future studies should focus on understanding the individual site-related effects.
format	article
author	Danny Baghdan Lara R. Dugas Candice Choo-Kang Jacob Plange-Rhule Pascal Bovet Bharathi Viswanathan Terrence Forrester Estelle V. Lambert Walter Riesen Wolfgang Korte Mashkoor A. Choudhry Amy Luke
author_facet	Danny Baghdan Lara R. Dugas Candice Choo-Kang Jacob Plange-Rhule Pascal Bovet Bharathi Viswanathan Terrence Forrester Estelle V. Lambert Walter Riesen Wolfgang Korte Mashkoor A. Choudhry Amy Luke
author_sort	Danny Baghdan
title	The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition
title_short	The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition
title_full	The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition
title_fullStr	The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition
title_full_unstemmed	The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition
title_sort	associations between alcohol intake and cardiometabolic risk in african-origin adults spanning the epidemiologic transition
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5d663d2cd1294cfb8bb0d8a1ff58194b
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The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition

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