The prognostic significance of Cdc6 and Cdt1 in breast cancer

Abstract DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers are largely unknown. In the present stu...

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Autores principales:	Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M. McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d67ca260d2d4a3ba651bf96ea3d89ef
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spelling	oai:doaj.org-article:5d67ca260d2d4a3ba651bf96ea3d89ef2021-12-02T15:05:10ZThe prognostic significance of Cdc6 and Cdt1 in breast cancer10.1038/s41598-017-00998-92045-2322https://doaj.org/article/5d67ca260d2d4a3ba651bf96ea3d89ef2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00998-9https://doaj.org/toc/2045-2322Abstract DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers are largely unknown. In the present study, we have shown that the expression levels of Cdc6 and Cdt1 were both significantly correlated with an increasing number of MCM2-7 genes overexpression. Both Cdc6 and Cdt1, when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort (n = 1441). In line with this finding, the expression of Cdc6 and Cdt1 was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 was significantly higher in ER negative breast cancer, and was suppressed when ER signalling was inhibited either by tamoxifen in vitro or letrozole in human subjects. Importantly, breast cancer patients who responded to letrozole expressed significantly lower Cdc6 than those patients who did not respond. Our results suggest that Cdc6 is a potential prognostic marker and therapeutic target in breast cancer patients.Ravikiran MahadevappaHenrique NevesShun Ming YuenYuchen BaiCian M. McCruddenHiu Fung YuenQing WenShu Dong ZhangHang Fai KwokNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ravikiran Mahadevappa Henrique Neves Shun Ming Yuen Yuchen Bai Cian M. McCrudden Hiu Fung Yuen Qing Wen Shu Dong Zhang Hang Fai Kwok The prognostic significance of Cdc6 and Cdt1 in breast cancer
description	Abstract DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers are largely unknown. In the present study, we have shown that the expression levels of Cdc6 and Cdt1 were both significantly correlated with an increasing number of MCM2-7 genes overexpression. Both Cdc6 and Cdt1, when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort (n = 1441). In line with this finding, the expression of Cdc6 and Cdt1 was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 was significantly higher in ER negative breast cancer, and was suppressed when ER signalling was inhibited either by tamoxifen in vitro or letrozole in human subjects. Importantly, breast cancer patients who responded to letrozole expressed significantly lower Cdc6 than those patients who did not respond. Our results suggest that Cdc6 is a potential prognostic marker and therapeutic target in breast cancer patients.
format	article
author	Ravikiran Mahadevappa Henrique Neves Shun Ming Yuen Yuchen Bai Cian M. McCrudden Hiu Fung Yuen Qing Wen Shu Dong Zhang Hang Fai Kwok
author_facet	Ravikiran Mahadevappa Henrique Neves Shun Ming Yuen Yuchen Bai Cian M. McCrudden Hiu Fung Yuen Qing Wen Shu Dong Zhang Hang Fai Kwok
author_sort	Ravikiran Mahadevappa
title	The prognostic significance of Cdc6 and Cdt1 in breast cancer
title_short	The prognostic significance of Cdc6 and Cdt1 in breast cancer
title_full	The prognostic significance of Cdc6 and Cdt1 in breast cancer
title_fullStr	The prognostic significance of Cdc6 and Cdt1 in breast cancer
title_full_unstemmed	The prognostic significance of Cdc6 and Cdt1 in breast cancer
title_sort	prognostic significance of cdc6 and cdt1 in breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5d67ca260d2d4a3ba651bf96ea3d89ef
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The prognostic significance of Cdc6 and Cdt1 in breast cancer

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