Experimental study of fat derived pellets promoting wound healing in rats

To observe the effect of fat derived pellets (FDP) on wound healing in rats. Methods: the inguinal fat of rats was obtained, and the FDP were obtained after centrifugation. The cell activity and growth factor secretion of FDP were measured. The wounds in rats were created and FDP was used to treat t...

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Autores principales:	Li Zeng, Shaolong Zhou, Chen Chen, Lin-hua Zhou, Xiujiang Shi, Zongjian Wu, Sheng-Kang Luo
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	stem cell physical method macrophages growth factors wound healing Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/5d68669020db44dba10fb9e35524c16c
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spelling	oai:doaj.org-article:5d68669020db44dba10fb9e35524c16c2021-11-26T11:19:49ZExperimental study of fat derived pellets promoting wound healing in rats2165-59792165-598710.1080/21655979.2021.2000257https://doaj.org/article/5d68669020db44dba10fb9e35524c16c2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2000257https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987To observe the effect of fat derived pellets (FDP) on wound healing in rats. Methods: the inguinal fat of rats was obtained, and the FDP were obtained after centrifugation. The cell activity and growth factor secretion of FDP were measured. The wounds in rats were created and FDP was used to treat the wound of rats. The phenotype of macrophages and the expression of angiogenic factors expression in wounds were measured. Results: the cell viability in FDP remains in high level after centrifugation and the expression of vascular endothelial growth factor (VEGF) and Basic Fibroblast Growth Facto (bFGF) from FDP was observed in vitro. The FDP significantly promoted the wound healing of rats compared with that in control groups. Moreover, the expression of M2 macrophages and VEGF in FDP group were significantly higher than that in the control group. Conclusion: FDP is a kind of stem cell product which can be obtained from adipose tissue by physical centrifugation. The cytotherapeutic effect of FDP makes it a promising product for wound healing in clinics.Li ZengShaolong ZhouChen ChenLin-hua ZhouXiujiang ShiZongjian WuSheng-Kang LuoTaylor & Francis Grouparticlestem cellphysical methodmacrophagesgrowth factorswound healingBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell physical method macrophages growth factors wound healing Biotechnology TP248.13-248.65
spellingShingle	stem cell physical method macrophages growth factors wound healing Biotechnology TP248.13-248.65 Li Zeng Shaolong Zhou Chen Chen Lin-hua Zhou Xiujiang Shi Zongjian Wu Sheng-Kang Luo Experimental study of fat derived pellets promoting wound healing in rats
description	To observe the effect of fat derived pellets (FDP) on wound healing in rats. Methods: the inguinal fat of rats was obtained, and the FDP were obtained after centrifugation. The cell activity and growth factor secretion of FDP were measured. The wounds in rats were created and FDP was used to treat the wound of rats. The phenotype of macrophages and the expression of angiogenic factors expression in wounds were measured. Results: the cell viability in FDP remains in high level after centrifugation and the expression of vascular endothelial growth factor (VEGF) and Basic Fibroblast Growth Facto (bFGF) from FDP was observed in vitro. The FDP significantly promoted the wound healing of rats compared with that in control groups. Moreover, the expression of M2 macrophages and VEGF in FDP group were significantly higher than that in the control group. Conclusion: FDP is a kind of stem cell product which can be obtained from adipose tissue by physical centrifugation. The cytotherapeutic effect of FDP makes it a promising product for wound healing in clinics.
format	article
author	Li Zeng Shaolong Zhou Chen Chen Lin-hua Zhou Xiujiang Shi Zongjian Wu Sheng-Kang Luo
author_facet	Li Zeng Shaolong Zhou Chen Chen Lin-hua Zhou Xiujiang Shi Zongjian Wu Sheng-Kang Luo
author_sort	Li Zeng
title	Experimental study of fat derived pellets promoting wound healing in rats
title_short	Experimental study of fat derived pellets promoting wound healing in rats
title_full	Experimental study of fat derived pellets promoting wound healing in rats
title_fullStr	Experimental study of fat derived pellets promoting wound healing in rats
title_full_unstemmed	Experimental study of fat derived pellets promoting wound healing in rats
title_sort	experimental study of fat derived pellets promoting wound healing in rats
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5d68669020db44dba10fb9e35524c16c
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_version_	1718409472993394688

Experimental study of fat derived pellets promoting wound healing in rats

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