Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.

Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors. A consecutive cohort of extremely low birth weight infants who survived to...

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Autores principales:	Nehal A Parikh, Robert E Lasky, Kathleen A Kennedy, Georgia McDavid, Jon E Tyson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d68fcda711843648afa3003eca141bb
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spelling	oai:doaj.org-article:5d68fcda711843648afa3003eca141bb2021-11-18T07:46:14ZPerinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.1932-620310.1371/journal.pone.0062804https://doaj.org/article/5d68fcda711843648afa3003eca141bb2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23671636/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors. A consecutive cohort of extremely low birth weight infants who survived to 38 weeks postmenstrual age (n = 122) and a control group of 16 healthy term newborns underwent brain MRI at term-equivalent age. Brain volumes were measured using semi-automated and manual segmentation methods. Using multivariable linear regression, clinical antecedents were correlated with volumes of total brain tissue, white matter hyperintensities, and regional tissues/structures, adjusted for age at MRI, total cranial volume, and total tissue volume. Regional brain volumes were markedly reduced in extremely low birth weight infants as compared to term newborns (relative difference range: -11.0%, -35.9%). Significant adverse clinical associations for total brain tissue volume included: small for gestational age, seizures, caffeine therapy/apnea of prematurity, duration of parenteral nutrition, pulmonary hemorrhage, and white matter injury (p<0.01 for each; relative difference range: -1.4% to -15.0%). Surgery for retinopathy of prematurity and surgery for necrotizing enterocolitis or spontaneous intestinal perforation were significantly associated with increasing volume of white matter hyperintensities. Regional brain volumes are sensitive to multiple perinatal factors and neonatal morbidities or interventions. Brain growth measurements in extremely low birth weight infants can advance our understanding of perinatal brain injury and development.Nehal A ParikhRobert E LaskyKathleen A KennedyGeorgia McDavidJon E TysonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e62804 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nehal A Parikh Robert E Lasky Kathleen A Kennedy Georgia McDavid Jon E Tyson Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
description	Our objective was to investigate diverse clinical antecedents of total and regional brain volume abnormalities and white matter hyperintensity volume on term MRI in extremely low birth weight (birth weight ≤1000 g) survivors. A consecutive cohort of extremely low birth weight infants who survived to 38 weeks postmenstrual age (n = 122) and a control group of 16 healthy term newborns underwent brain MRI at term-equivalent age. Brain volumes were measured using semi-automated and manual segmentation methods. Using multivariable linear regression, clinical antecedents were correlated with volumes of total brain tissue, white matter hyperintensities, and regional tissues/structures, adjusted for age at MRI, total cranial volume, and total tissue volume. Regional brain volumes were markedly reduced in extremely low birth weight infants as compared to term newborns (relative difference range: -11.0%, -35.9%). Significant adverse clinical associations for total brain tissue volume included: small for gestational age, seizures, caffeine therapy/apnea of prematurity, duration of parenteral nutrition, pulmonary hemorrhage, and white matter injury (p<0.01 for each; relative difference range: -1.4% to -15.0%). Surgery for retinopathy of prematurity and surgery for necrotizing enterocolitis or spontaneous intestinal perforation were significantly associated with increasing volume of white matter hyperintensities. Regional brain volumes are sensitive to multiple perinatal factors and neonatal morbidities or interventions. Brain growth measurements in extremely low birth weight infants can advance our understanding of perinatal brain injury and development.
format	article
author	Nehal A Parikh Robert E Lasky Kathleen A Kennedy Georgia McDavid Jon E Tyson
author_facet	Nehal A Parikh Robert E Lasky Kathleen A Kennedy Georgia McDavid Jon E Tyson
author_sort	Nehal A Parikh
title	Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
title_short	Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
title_full	Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
title_fullStr	Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
title_full_unstemmed	Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
title_sort	perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5d68fcda711843648afa3003eca141bb
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Perinatal factors and regional brain volume abnormalities at term in a cohort of extremely low birth weight infants.

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