Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action

Safieh Firouzi,1,2,* Mahsa Malekahmadi,1,2,* Majid Ghayour-Mobarhan,1,3 Gordon Ferns,4 Hamid Reza Rahimi3,5 1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 2Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; 3Department of M...

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Autores principales:	Firouzi S, Malekahmadi M, Ghayour-Mobarhan M, Ferns G, Rahimi HR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	berberine syndrome metabolic obesity Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/5d68fe9a98a94a668414bc3697c1a576
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spelling	oai:doaj.org-article:5d68fe9a98a94a668414bc3697c1a5762021-12-02T07:05:54ZBarberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action1178-7007https://doaj.org/article/5d68fe9a98a94a668414bc3697c1a5762018-11-01T00:00:00Zhttps://www.dovepress.com/barberry-in-the-treatment-of-obesity-and-metabolic-syndrome-possible-m-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Safieh Firouzi,1,2,* Mahsa Malekahmadi,1,2,* Majid Ghayour-Mobarhan,1,3 Gordon Ferns,4 Hamid Reza Rahimi3,5 1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 2Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; 3Department of Modern Sciences and Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 4Department of Medical Education, Brighton and Sussex Medical School, University of Brighton Falmer Campus, Brighton, UK; 5Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran *These authors contributed equally to this work Abstract: Obesity is a consequence of an imbalance between energy intake and energy expenditure. It affects people of both genders and all age groups, ethnicity and socioeconomic groups, and in developed and developing countries. Obesity is often accompanied by the metabolic syndrome (MetS). MetS is characterized by a clustering of cardiovascular risk factors, including high blood pressure, adiposity, dyslipidemia and glucose intolerance, which together increase the risk of atherosclerotic cardiovascular disease, type 2 diabetes mellitus and other causes of mortality. Nowadays, there is a growing interest in the use of plant-based agents instead of synthetic drugs to manage chronic diseases such as MetS; one such example is Berberis vulgaris. B. vulgaris contains isoquinonline alkaloids such as berberine, berberrubine and berbamine. Recent studies have proved that berberine exhibits pharmacological activities and positive effects on the risk factors of obesity and MetS. We have reviewed original articles related to the possible molecular mechanisms of action of berberine on obesity and MetS. Berberine suppresses adipocyte differentiation and decreases obesity. It also regulates glucose metabolism via decreasing insulin resistance and increasing insulin secretion. Other effects of berberine include antihyperlipidemic and antihypertensive activities and endothelial protection. Keywords: berberine, syndrome metabolic, obesity Firouzi SMalekahmadi MGhayour-Mobarhan MFerns GRahimi HRDove Medical Pressarticleberberinesyndrome metabolicobesitySpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 699-705 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	berberine syndrome metabolic obesity Specialties of internal medicine RC581-951
spellingShingle	berberine syndrome metabolic obesity Specialties of internal medicine RC581-951 Firouzi S Malekahmadi M Ghayour-Mobarhan M Ferns G Rahimi HR Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
description	Safieh Firouzi,1,2,* Mahsa Malekahmadi,1,2,* Majid Ghayour-Mobarhan,1,3 Gordon Ferns,4 Hamid Reza Rahimi3,5 1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; 2Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran; 3Department of Modern Sciences and Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; 4Department of Medical Education, Brighton and Sussex Medical School, University of Brighton Falmer Campus, Brighton, UK; 5Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran *These authors contributed equally to this work Abstract: Obesity is a consequence of an imbalance between energy intake and energy expenditure. It affects people of both genders and all age groups, ethnicity and socioeconomic groups, and in developed and developing countries. Obesity is often accompanied by the metabolic syndrome (MetS). MetS is characterized by a clustering of cardiovascular risk factors, including high blood pressure, adiposity, dyslipidemia and glucose intolerance, which together increase the risk of atherosclerotic cardiovascular disease, type 2 diabetes mellitus and other causes of mortality. Nowadays, there is a growing interest in the use of plant-based agents instead of synthetic drugs to manage chronic diseases such as MetS; one such example is Berberis vulgaris. B. vulgaris contains isoquinonline alkaloids such as berberine, berberrubine and berbamine. Recent studies have proved that berberine exhibits pharmacological activities and positive effects on the risk factors of obesity and MetS. We have reviewed original articles related to the possible molecular mechanisms of action of berberine on obesity and MetS. Berberine suppresses adipocyte differentiation and decreases obesity. It also regulates glucose metabolism via decreasing insulin resistance and increasing insulin secretion. Other effects of berberine include antihyperlipidemic and antihypertensive activities and endothelial protection. Keywords: berberine, syndrome metabolic, obesity
format	article
author	Firouzi S Malekahmadi M Ghayour-Mobarhan M Ferns G Rahimi HR
author_facet	Firouzi S Malekahmadi M Ghayour-Mobarhan M Ferns G Rahimi HR
author_sort	Firouzi S
title	Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
title_short	Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
title_full	Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
title_fullStr	Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
title_full_unstemmed	Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
title_sort	barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5d68fe9a98a94a668414bc3697c1a576
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Barberry in the treatment of obesity and metabolic syndrome: possible mechanisms of action

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