Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis

Reihane Mohammadi,1 Alisam Aryan,2 Mir Davood Omrani,1 Sayyed Mohammad Hossein Ghaderian,1 Zahra Fazeli1 1Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohammadi R, Aryan A, Omrani MD, Ghaderian SMH, Fazeli Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	autologous hematopoietic stem cells transplantation multiple sclerosis molecular mechanisms resetting immune system Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5d6b6b9d8254457c8060ea122c2cfdb4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d6b6b9d8254457c8060ea122c2cfdb4
record_format	dspace
spelling	oai:doaj.org-article:5d6b6b9d8254457c8060ea122c2cfdb42021-12-02T13:36:17ZAutologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis1177-5491https://doaj.org/article/5d6b6b9d8254457c8060ea122c2cfdb42021-03-01T00:00:00Zhttps://www.dovepress.com/autologous-hematopoietic-stem-cell-transplantation-ahsct-an-evolving-t-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Reihane Mohammadi,1 Alisam Aryan,2 Mir Davood Omrani,1 Sayyed Mohammad Hossein Ghaderian,1 Zahra Fazeli1 1Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranCorrespondence: Zahra FazeliDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranEmail Z.Fazeli@sbmu.ac.irAbstract: Autologous hematopoietic stem cell transplantation (AHSCT) is considered as the novel approach to improve multiple sclerosis (MS) patients with disease-modifying therapies (DMTs)-resistance. The results obtained from different studies indicate that AHSCT increases the life quality of MS patients. Several factors are known to be influenced on the successful rate of AHSCT in patients with MS. The individuals aged < 40 years with a short duration of MS disease have been demonstrated to show a better response to AHSCT administration. Furthermore, this treatment approach was more effective in relapsing remitting MS (RRMS) patients than progressive MS (PMS). Different clinical trials revealed that AHSCT with a low density conditioning regimen could be suggested as a suitable candidate approach in the management of MS. Several molecular and cellular mechanisms are known to be involved in the resetting of the immune system following the AHSCT infusion in MS patients. These mechanisms play a role in the depletion of auto-reactive lymphocytes and immune system renewal. In the present review, we discuss different clinical and molecular aspects of AHSCT application in the alleviation of MS symptoms.Keywords: autologous hematopoietic stem cells, transplantation, multiple sclerosis, molecular mechanisms, resetting immune systemMohammadi RAryan AOmrani MDGhaderian SMHFazeli ZDove Medical Pressarticleautologous hematopoietic stem cellstransplantationmultiple sclerosismolecular mechanismsresetting immune systemMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 15, Pp 53-59 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autologous hematopoietic stem cells transplantation multiple sclerosis molecular mechanisms resetting immune system Medicine (General) R5-920
spellingShingle	autologous hematopoietic stem cells transplantation multiple sclerosis molecular mechanisms resetting immune system Medicine (General) R5-920 Mohammadi R Aryan A Omrani MD Ghaderian SMH Fazeli Z Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis
description	Reihane Mohammadi,1 Alisam Aryan,2 Mir Davood Omrani,1 Sayyed Mohammad Hossein Ghaderian,1 Zahra Fazeli1 1Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranCorrespondence: Zahra FazeliDepartment of Medical Genetics, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranEmail Z.Fazeli@sbmu.ac.irAbstract: Autologous hematopoietic stem cell transplantation (AHSCT) is considered as the novel approach to improve multiple sclerosis (MS) patients with disease-modifying therapies (DMTs)-resistance. The results obtained from different studies indicate that AHSCT increases the life quality of MS patients. Several factors are known to be influenced on the successful rate of AHSCT in patients with MS. The individuals aged < 40 years with a short duration of MS disease have been demonstrated to show a better response to AHSCT administration. Furthermore, this treatment approach was more effective in relapsing remitting MS (RRMS) patients than progressive MS (PMS). Different clinical trials revealed that AHSCT with a low density conditioning regimen could be suggested as a suitable candidate approach in the management of MS. Several molecular and cellular mechanisms are known to be involved in the resetting of the immune system following the AHSCT infusion in MS patients. These mechanisms play a role in the depletion of auto-reactive lymphocytes and immune system renewal. In the present review, we discuss different clinical and molecular aspects of AHSCT application in the alleviation of MS symptoms.Keywords: autologous hematopoietic stem cells, transplantation, multiple sclerosis, molecular mechanisms, resetting immune system
format	article
author	Mohammadi R Aryan A Omrani MD Ghaderian SMH Fazeli Z
author_facet	Mohammadi R Aryan A Omrani MD Ghaderian SMH Fazeli Z
author_sort	Mohammadi R
title	Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis
title_short	Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis
title_full	Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis
title_fullStr	Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis
title_full_unstemmed	Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis
title_sort	autologous hematopoietic stem cell transplantation (ahsct): an evolving treatment avenue in multiple sclerosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/5d6b6b9d8254457c8060ea122c2cfdb4
work_keys_str_mv	AT mohammadir autologoushematopoieticstemcelltransplantationahsctanevolvingtreatmentavenueinmultiplesclerosis AT aryana autologoushematopoieticstemcelltransplantationahsctanevolvingtreatmentavenueinmultiplesclerosis AT omranimd autologoushematopoieticstemcelltransplantationahsctanevolvingtreatmentavenueinmultiplesclerosis AT ghaderiansmh autologoushematopoieticstemcelltransplantationahsctanevolvingtreatmentavenueinmultiplesclerosis AT fazeliz autologoushematopoieticstemcelltransplantationahsctanevolvingtreatmentavenueinmultiplesclerosis
_version_	1718392675271442432

Autologous Hematopoietic Stem Cell Transplantation (AHSCT): An Evolving Treatment Avenue in Multiple Sclerosis

Ejemplares similares