Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy
Despite evidence for microstructural brain alterations in epilepsy patients, little is known about how these develop with age and the progress of the disease. The aim of this study was to investigate microstructural abnormalities of the white matter (WM) in children with new-onset, untreated idiopat...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:5d6d77d2bf104c979bfc4f0c7db85f752021-12-01T16:48:30ZAbnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy1664-229510.3389/fneur.2021.744723https://doaj.org/article/5d6d77d2bf104c979bfc4f0c7db85f752021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.744723/fullhttps://doaj.org/toc/1664-2295Despite evidence for microstructural brain alterations in epilepsy patients, little is known about how these develop with age and the progress of the disease. The aim of this study was to investigate microstructural abnormalities of the white matter (WM) in children with new-onset, untreated idiopathic-generalized epilepsy (IGE) using the MRI technique of diffusion tensor imaging (DTI). The study was approved by the institutional review board, and all individuals or their parents gave signed informed consent. In total, 45 patients with IGE (age 5–18 years, male: female 26:19) and 32 healthy controls (HCs; age 5–18 years, male: female 21:11) were included. Voxel-based analysis (VBA) was used to compare patients and controls, and Pearson correlation analysis was used to investigate relationships between altered DTI metrics and clinical parameters. Compared with controls, patients with IGE showed increased mean diffusivity (MD) in the left splenium of the corpus callosum, increased fractional anisotropy (FA) in the right WM of the superior and middle frontal gyri, increased axial diffusivity (AD) in the WM of right corona radiata and left occipital lobe, and decreased AD in the WM of the left thalamus and the right middle cerebellar peduncle. There was no correlation between the altered diffusion parameters and clinical measures. Our study demonstrated several distinct microstructural impairments in children with new-onset, untreated IGE, of which altered AD might be the most sensitive marker of dysmyelination. The increased FA in the IGE group might suggest an initiating or compensatory mechanism that is activated prior to cognitive decline in these children.Ran LongYuting WangYuting WangLizhou ChenDingmei DengLan MeiJingping MouGuangcai TangFugang HanGraham John KempQiyong GongLihua QiuLihua QiuFrontiers Media S.A.articleepilepsywhite matterdiffusionanisotropycognitionNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021) |
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epilepsy white matter diffusion anisotropy cognition Neurology. Diseases of the nervous system RC346-429 |
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epilepsy white matter diffusion anisotropy cognition Neurology. Diseases of the nervous system RC346-429 Ran Long Yuting Wang Yuting Wang Lizhou Chen Dingmei Deng Lan Mei Jingping Mou Guangcai Tang Fugang Han Graham John Kemp Qiyong Gong Lihua Qiu Lihua Qiu Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy |
| description |
Despite evidence for microstructural brain alterations in epilepsy patients, little is known about how these develop with age and the progress of the disease. The aim of this study was to investigate microstructural abnormalities of the white matter (WM) in children with new-onset, untreated idiopathic-generalized epilepsy (IGE) using the MRI technique of diffusion tensor imaging (DTI). The study was approved by the institutional review board, and all individuals or their parents gave signed informed consent. In total, 45 patients with IGE (age 5–18 years, male: female 26:19) and 32 healthy controls (HCs; age 5–18 years, male: female 21:11) were included. Voxel-based analysis (VBA) was used to compare patients and controls, and Pearson correlation analysis was used to investigate relationships between altered DTI metrics and clinical parameters. Compared with controls, patients with IGE showed increased mean diffusivity (MD) in the left splenium of the corpus callosum, increased fractional anisotropy (FA) in the right WM of the superior and middle frontal gyri, increased axial diffusivity (AD) in the WM of right corona radiata and left occipital lobe, and decreased AD in the WM of the left thalamus and the right middle cerebellar peduncle. There was no correlation between the altered diffusion parameters and clinical measures. Our study demonstrated several distinct microstructural impairments in children with new-onset, untreated IGE, of which altered AD might be the most sensitive marker of dysmyelination. The increased FA in the IGE group might suggest an initiating or compensatory mechanism that is activated prior to cognitive decline in these children. |
| format |
article |
| author |
Ran Long Yuting Wang Yuting Wang Lizhou Chen Dingmei Deng Lan Mei Jingping Mou Guangcai Tang Fugang Han Graham John Kemp Qiyong Gong Lihua Qiu Lihua Qiu |
| author_facet |
Ran Long Yuting Wang Yuting Wang Lizhou Chen Dingmei Deng Lan Mei Jingping Mou Guangcai Tang Fugang Han Graham John Kemp Qiyong Gong Lihua Qiu Lihua Qiu |
| author_sort |
Ran Long |
| title |
Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy |
| title_short |
Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy |
| title_full |
Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy |
| title_fullStr |
Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy |
| title_full_unstemmed |
Abnormalities of Cerebral White Matter Microstructure in Children With New-Onset, Untreated Idiopathic-Generalized Epilepsy |
| title_sort |
abnormalities of cerebral white matter microstructure in children with new-onset, untreated idiopathic-generalized epilepsy |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/5d6d77d2bf104c979bfc4f0c7db85f75 |
| work_keys_str_mv |
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