Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters

Objective: To study the effects of different psychotropic drugs on sleep architecture and sleep-related disorders. Material and Methods: In this retrospective review of 405 consecutive de-identiﬁed diagnostic polysomnograms performed at a sleep laboratory from 2007 until 2011, we grouped 34...

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Autores principales:	Elias Ghossoub, Luna Geagea, Firas Kobeissy, Farid Talih
Formato:	article
Lenguaje:	EN
Publicado:	Brazilian Association of Sleep and Latin American Federation of Sleep Societies 2021
Materias:	sleep wake disorders nocturnal myoclonus syndrome periodic limb movements disorder sleep apnea Psychology BF1-990 Consciousness. Cognition BF309-499
Acceso en línea:	https://doaj.org/article/5d6fd6ebd64442bb86a2564f9523cdc7
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spelling	oai:doaj.org-article:5d6fd6ebd64442bb86a2564f9523cdc72021-11-24T12:26:11ZComparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters1984-06591984-0063000810.5935/1984-0063.20200071https://doaj.org/article/5d6fd6ebd64442bb86a2564f9523cdc72021-10-01T00:00:00Zhttps://www.sleepscience.org.br/details/2822/en-US/comparative-effects-of-psychotropic-medications-on-sleep-architecture--a-retrospective-review-of-diagnostic-polysomnography-sleep-parametershttps://doaj.org/toc/1984-0659https://doaj.org/toc/1984-0063Objective: To study the effects of different psychotropic drugs on sleep architecture and sleep-related disorders. Material and Methods: In this retrospective review of 405 consecutive de-identiﬁed diagnostic polysomnograms performed at a sleep laboratory from 2007 until 2011, we grouped 347 polysomnograms into ﬁve categories: controls, antidepressants (AD), antidepressants + anticonvulsants (ADAC), antidepressants + antipsychotics (ADAP), antidepressants + anticonvulsants + antipsychotics (ADACP). We conducted pairwise comparisons for demographic characteristics, medical history, speciﬁc psychotropic medication uses and sleep architecture variables, and adjusted for multiple testing. We used logistic regression to determine the odds ratio of having elevated apnea-hypopnea index (AHI) and periodic limb movement index (PLMI) within each group as compared to controls. Results: Compared to controls, all groups had a signiﬁcantly higher prevalence of benzodiazepines and trazodone use. AD and ADACP had signiﬁcantly longer REM latency and lower REM percentage of total sleep time compared to controls. ADAP had a signiﬁcantly lower AHI compared to controls, but that association was lost in the regression model. AD was associated with a higher PLMI compared to controls. Conclusion: Psychotropic polypharmacy does not seem to be associated with significantly deleterious effects on sleep architecture. Adjunct anticonvulsants or antipsychotics to antidepressants may protect against periodic limb movement disorder.Elias GhossoubLuna GeageaFiras KobeissyFarid TalihBrazilian Association of Sleep and Latin American Federation of Sleep Societies articlesleep wake disordersnocturnal myoclonus syndromeperiodic limb movements disordersleep apneaPsychologyBF1-990Consciousness. CognitionBF309-499ENSleep Science, Vol 14, Iss 3, Pp 236-244 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sleep wake disorders nocturnal myoclonus syndrome periodic limb movements disorder sleep apnea Psychology BF1-990 Consciousness. Cognition BF309-499
spellingShingle	sleep wake disorders nocturnal myoclonus syndrome periodic limb movements disorder sleep apnea Psychology BF1-990 Consciousness. Cognition BF309-499 Elias Ghossoub Luna Geagea Firas Kobeissy Farid Talih Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
description	Objective: To study the effects of different psychotropic drugs on sleep architecture and sleep-related disorders. Material and Methods: In this retrospective review of 405 consecutive de-identiﬁed diagnostic polysomnograms performed at a sleep laboratory from 2007 until 2011, we grouped 347 polysomnograms into ﬁve categories: controls, antidepressants (AD), antidepressants + anticonvulsants (ADAC), antidepressants + antipsychotics (ADAP), antidepressants + anticonvulsants + antipsychotics (ADACP). We conducted pairwise comparisons for demographic characteristics, medical history, speciﬁc psychotropic medication uses and sleep architecture variables, and adjusted for multiple testing. We used logistic regression to determine the odds ratio of having elevated apnea-hypopnea index (AHI) and periodic limb movement index (PLMI) within each group as compared to controls. Results: Compared to controls, all groups had a signiﬁcantly higher prevalence of benzodiazepines and trazodone use. AD and ADACP had signiﬁcantly longer REM latency and lower REM percentage of total sleep time compared to controls. ADAP had a signiﬁcantly lower AHI compared to controls, but that association was lost in the regression model. AD was associated with a higher PLMI compared to controls. Conclusion: Psychotropic polypharmacy does not seem to be associated with significantly deleterious effects on sleep architecture. Adjunct anticonvulsants or antipsychotics to antidepressants may protect against periodic limb movement disorder.
format	article
author	Elias Ghossoub Luna Geagea Firas Kobeissy Farid Talih
author_facet	Elias Ghossoub Luna Geagea Firas Kobeissy Farid Talih
author_sort	Elias Ghossoub
title	Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
title_short	Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
title_full	Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
title_fullStr	Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
title_full_unstemmed	Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
title_sort	comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters
publisher	Brazilian Association of Sleep and Latin American Federation of Sleep Societies
publishDate	2021
url	https://doaj.org/article/5d6fd6ebd64442bb86a2564f9523cdc7
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Comparative effects of psychotropic medications on sleep architecture: a retrospective review of diagnostic polysomnography sleep parameters

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