Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users

Background: During cocaine withdrawal, transient depressive symptoms that do not meet the criteria for depression, but promote relapse, are frequently observed. Their temporality could evoke a role of dopamine, especially since the underlying mechanism of these depressive symptoms is not well unders...

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Autores principales:	Julien Cabé, Georges Brousse, Bruno Pereira, Nicolas Cabé, Emily Karsinti, El-Hadi Zerdazi, Romain Icick, Pierre M. Llorca, Vanessa Bloch, Florence Vorspan, Ingrid De Chazeron
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cocaine withdrawal dopamine clinical markers depressive symptoms Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/5d701526492740e09ee829d779b7f3fa
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spelling	oai:doaj.org-article:5d701526492740e09ee829d779b7f3fa2021-11-22T06:28:32ZInfluence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users1664-064010.3389/fpsyt.2021.775670https://doaj.org/article/5d701526492740e09ee829d779b7f3fa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.775670/fullhttps://doaj.org/toc/1664-0640Background: During cocaine withdrawal, transient depressive symptoms that do not meet the criteria for depression, but promote relapse, are frequently observed. Their temporality could evoke a role of dopamine, especially since the underlying mechanism of these depressive symptoms is not well understood. We hypothesized that variation in the dopaminergic activity profile, modeled from clinical markers, could be implicated in the development of depressive symptoms during cocaine withdrawal.Methods: We compared patients reporting depressive symptoms (RDS+) or not (RDS–) during cocaine withdrawal. We evaluated dopaminergic activity through indirect clinical markers based on the known dopaminergic behaviors. A combined criterion was constructed for hyper and hypo dopaminergic models according to the O'Brien method and illustrated by the Hedges' effect-size and forest-plot graph. A multidimensional factorial analysis was carried out to determine which parameters discriminate RDS+/RDS– patients.Results: 313 patients were included, and 77% reported depressive symptoms during cocaine withdrawal. Hyperdopaminergic variables used to discriminate the two groups had a large overall effect size (−0.669) and included psychotic symptoms (−0.524), hallucinations (−0.548), and delusions (−0.528). The overall effect of the hypodopaminergic component was considerable (−0.604) with a large effect size for the severity of dependence (−0.616), withdrawal symptoms (−0.578), and anhedonia (−0.528). The combined model including hyperdopaminergic and hypodopaminergic components had the largest effect size (−0.785).Conclusion: The dopaminergic activities profile, assessed by indirect clinical markers, seems to characterize patients with depressive symptoms very well during cocaine withdrawal. RDS+ patients reported moreover higher levels of psychotic symptoms and more severe cocaine use disorder than RDS–.Julien CabéJulien CabéJulien CabéGeorges BrousseGeorges BrousseGeorges BrousseBruno PereiraNicolas CabéNicolas CabéEmily KarsintiEmily KarsintiEl-Hadi ZerdaziEl-Hadi ZerdaziRomain IcickRomain IcickPierre M. LlorcaPierre M. LlorcaPierre M. LlorcaVanessa BlochVanessa BlochVanessa BlochFlorence VorspanFlorence VorspanFlorence VorspanIngrid De ChazeronIngrid De ChazeronIngrid De ChazeronFrontiers Media S.A.articlecocainewithdrawaldopamineclinical markersdepressive symptomsPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cocaine withdrawal dopamine clinical markers depressive symptoms Psychiatry RC435-571
spellingShingle	cocaine withdrawal dopamine clinical markers depressive symptoms Psychiatry RC435-571 Julien Cabé Julien Cabé Julien Cabé Georges Brousse Georges Brousse Georges Brousse Bruno Pereira Nicolas Cabé Nicolas Cabé Emily Karsinti Emily Karsinti El-Hadi Zerdazi El-Hadi Zerdazi Romain Icick Romain Icick Pierre M. Llorca Pierre M. Llorca Pierre M. Llorca Vanessa Bloch Vanessa Bloch Vanessa Bloch Florence Vorspan Florence Vorspan Florence Vorspan Ingrid De Chazeron Ingrid De Chazeron Ingrid De Chazeron Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users
description	Background: During cocaine withdrawal, transient depressive symptoms that do not meet the criteria for depression, but promote relapse, are frequently observed. Their temporality could evoke a role of dopamine, especially since the underlying mechanism of these depressive symptoms is not well understood. We hypothesized that variation in the dopaminergic activity profile, modeled from clinical markers, could be implicated in the development of depressive symptoms during cocaine withdrawal.Methods: We compared patients reporting depressive symptoms (RDS+) or not (RDS–) during cocaine withdrawal. We evaluated dopaminergic activity through indirect clinical markers based on the known dopaminergic behaviors. A combined criterion was constructed for hyper and hypo dopaminergic models according to the O'Brien method and illustrated by the Hedges' effect-size and forest-plot graph. A multidimensional factorial analysis was carried out to determine which parameters discriminate RDS+/RDS– patients.Results: 313 patients were included, and 77% reported depressive symptoms during cocaine withdrawal. Hyperdopaminergic variables used to discriminate the two groups had a large overall effect size (−0.669) and included psychotic symptoms (−0.524), hallucinations (−0.548), and delusions (−0.528). The overall effect of the hypodopaminergic component was considerable (−0.604) with a large effect size for the severity of dependence (−0.616), withdrawal symptoms (−0.578), and anhedonia (−0.528). The combined model including hyperdopaminergic and hypodopaminergic components had the largest effect size (−0.785).Conclusion: The dopaminergic activities profile, assessed by indirect clinical markers, seems to characterize patients with depressive symptoms very well during cocaine withdrawal. RDS+ patients reported moreover higher levels of psychotic symptoms and more severe cocaine use disorder than RDS–.
format	article
author	Julien Cabé Julien Cabé Julien Cabé Georges Brousse Georges Brousse Georges Brousse Bruno Pereira Nicolas Cabé Nicolas Cabé Emily Karsinti Emily Karsinti El-Hadi Zerdazi El-Hadi Zerdazi Romain Icick Romain Icick Pierre M. Llorca Pierre M. Llorca Pierre M. Llorca Vanessa Bloch Vanessa Bloch Vanessa Bloch Florence Vorspan Florence Vorspan Florence Vorspan Ingrid De Chazeron Ingrid De Chazeron Ingrid De Chazeron
author_facet	Julien Cabé Julien Cabé Julien Cabé Georges Brousse Georges Brousse Georges Brousse Bruno Pereira Nicolas Cabé Nicolas Cabé Emily Karsinti Emily Karsinti El-Hadi Zerdazi El-Hadi Zerdazi Romain Icick Romain Icick Pierre M. Llorca Pierre M. Llorca Pierre M. Llorca Vanessa Bloch Vanessa Bloch Vanessa Bloch Florence Vorspan Florence Vorspan Florence Vorspan Ingrid De Chazeron Ingrid De Chazeron Ingrid De Chazeron
author_sort	Julien Cabé
title	Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users
title_short	Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users
title_full	Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users
title_fullStr	Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users
title_full_unstemmed	Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users
title_sort	influence of clinical markers of dopaminergic behaviors on depressive symptoms during withdrawal in cocaine users
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5d701526492740e09ee829d779b7f3fa
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Influence of Clinical Markers of Dopaminergic Behaviors on Depressive Symptoms During Withdrawal in Cocaine Users

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