Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation

Conformational changes of HIV’s Env protein are required for its function in fusing the viral and host cell membranes. Here the authors describe how two small molecules alter the confirmation of Env trimers, and show they can induce structural changes similar to those occur upon receptor binding.

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Autores principales: Claudia A. Jette, Christopher O. Barnes, Sharon M. Kirk, Bruno Melillo, Amos B. Smith, Pamela J. Bjorkman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/5d705e751653456d99a85bb8fb085d65
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spelling oai:doaj.org-article:5d705e751653456d99a85bb8fb085d652021-12-02T13:27:03ZCryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation10.1038/s41467-021-21816-x2041-1723https://doaj.org/article/5d705e751653456d99a85bb8fb085d652021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21816-xhttps://doaj.org/toc/2041-1723Conformational changes of HIV’s Env protein are required for its function in fusing the viral and host cell membranes. Here the authors describe how two small molecules alter the confirmation of Env trimers, and show they can induce structural changes similar to those occur upon receptor binding.Claudia A. JetteChristopher O. BarnesSharon M. KirkBruno MelilloAmos B. SmithPamela J. BjorkmanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Claudia A. Jette
Christopher O. Barnes
Sharon M. Kirk
Bruno Melillo
Amos B. Smith
Pamela J. Bjorkman
Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation
description Conformational changes of HIV’s Env protein are required for its function in fusing the viral and host cell membranes. Here the authors describe how two small molecules alter the confirmation of Env trimers, and show they can induce structural changes similar to those occur upon receptor binding.
format article
author Claudia A. Jette
Christopher O. Barnes
Sharon M. Kirk
Bruno Melillo
Amos B. Smith
Pamela J. Bjorkman
author_facet Claudia A. Jette
Christopher O. Barnes
Sharon M. Kirk
Bruno Melillo
Amos B. Smith
Pamela J. Bjorkman
author_sort Claudia A. Jette
title Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation
title_short Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation
title_full Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation
title_fullStr Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation
title_full_unstemmed Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation
title_sort cryo-em structures of hiv-1 trimer bound to cd4-mimetics bnm-iii-170 and m48u1 adopt a cd4-bound open conformation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/5d705e751653456d99a85bb8fb085d65
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