Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterizat...

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Autores principales:	Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, Dong-Sheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang, Bing Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5d727e2e509d4204b777b2789c0541c6
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spelling	oai:doaj.org-article:5d727e2e509d4204b777b2789c0541c62021-12-02T19:17:00ZChromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation10.1038/s41467-020-18638-82041-1723https://doaj.org/article/5d727e2e509d4204b777b2789c0541c62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18638-8https://doaj.org/toc/2041-1723Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.Jingxue XinHui ZhangYaoxi HeZhana DurenCaijuan BaiLang ChenXin LuoDong-Sheng YanChaoyu ZhangXiang ZhuQiuyue YuanZhanying FengChaoying CuiXuebin QiOuzhuluobuWing Hung WongYong WangBing SuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingxue Xin Hui Zhang Yaoxi He Zhana Duren Caijuan Bai Lang Chen Xin Luo Dong-Sheng Yan Chaoyu Zhang Xiang Zhu Qiuyue Yuan Zhanying Feng Chaoying Cui Xuebin Qi Ouzhuluobu Wing Hung Wong Yong Wang Bing Su Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
description	Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.
format	article
author	Jingxue Xin Hui Zhang Yaoxi He Zhana Duren Caijuan Bai Lang Chen Xin Luo Dong-Sheng Yan Chaoyu Zhang Xiang Zhu Qiuyue Yuan Zhanying Feng Chaoying Cui Xuebin Qi Ouzhuluobu Wing Hung Wong Yong Wang Bing Su
author_facet	Jingxue Xin Hui Zhang Yaoxi He Zhana Duren Caijuan Bai Lang Chen Xin Luo Dong-Sheng Yan Chaoyu Zhang Xiang Zhu Qiuyue Yuan Zhanying Feng Chaoying Cui Xuebin Qi Ouzhuluobu Wing Hung Wong Yong Wang Bing Su
author_sort	Jingxue Xin
title	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_short	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_full	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_fullStr	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_full_unstemmed	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_sort	chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5d727e2e509d4204b777b2789c0541c6
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Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

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