Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.

Yeasts are leading model organisms for mitochondrial genome studies. The explosion of complete sequence of yeast mitochondrial (mt) genomes revealed a wide diversity of organization and structure between species. Recently, genome-wide polymorphism survey on the mt genome of isolates of a single spec...

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Autores principales:	Anne Friedrich, Paul P Jung, Jing Hou, Cécile Neuvéglise, Joseph Schacherer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d73a3db6f12418db7fee8da696e21ca
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spelling	oai:doaj.org-article:5d73a3db6f12418db7fee8da696e21ca2021-11-18T08:11:10ZComparative mitochondrial genomics within and among yeast species of the Lachancea genus.1932-620310.1371/journal.pone.0047834https://doaj.org/article/5d73a3db6f12418db7fee8da696e21ca2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23112855/?tool=EBIhttps://doaj.org/toc/1932-6203Yeasts are leading model organisms for mitochondrial genome studies. The explosion of complete sequence of yeast mitochondrial (mt) genomes revealed a wide diversity of organization and structure between species. Recently, genome-wide polymorphism survey on the mt genome of isolates of a single species, Lachancea kluyveri, was also performed. To compare the mitochondrial genome evolution at two hierarchical levels: within and among closely related species, we focused on five species of the Lachancea genus, which are close relatives of L. kluyveri. Hence, we sequenced the complete mt genome of L. dasiensis, L. nothofagi, L. mirantina, L. fantastica and L. meyersii. The phylogeny of the Lachancea genus was explored using these data. Analysis of intra- and interspecific variability across the whole Lachancea genus led to the same conclusions regarding the mitochondrial genome evolution. These genomes exhibit a similar architecture and are completely syntenic. Nevertheless, genome sizes vary considerably because of the variations of the intergenic regions and the intron content, contributing to mitochondrial genome plasticity. The high variability of the intergenic regions stands in contrast to the high level of similarity of protein sequences. Quantification of the selective constraints clearly revealed that most of the mitochondrial genes are under purifying selection in the whole genus.Anne FriedrichPaul P JungJing HouCécile NeuvégliseJoseph SchachererPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47834 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anne Friedrich Paul P Jung Jing Hou Cécile Neuvéglise Joseph Schacherer Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.
description	Yeasts are leading model organisms for mitochondrial genome studies. The explosion of complete sequence of yeast mitochondrial (mt) genomes revealed a wide diversity of organization and structure between species. Recently, genome-wide polymorphism survey on the mt genome of isolates of a single species, Lachancea kluyveri, was also performed. To compare the mitochondrial genome evolution at two hierarchical levels: within and among closely related species, we focused on five species of the Lachancea genus, which are close relatives of L. kluyveri. Hence, we sequenced the complete mt genome of L. dasiensis, L. nothofagi, L. mirantina, L. fantastica and L. meyersii. The phylogeny of the Lachancea genus was explored using these data. Analysis of intra- and interspecific variability across the whole Lachancea genus led to the same conclusions regarding the mitochondrial genome evolution. These genomes exhibit a similar architecture and are completely syntenic. Nevertheless, genome sizes vary considerably because of the variations of the intergenic regions and the intron content, contributing to mitochondrial genome plasticity. The high variability of the intergenic regions stands in contrast to the high level of similarity of protein sequences. Quantification of the selective constraints clearly revealed that most of the mitochondrial genes are under purifying selection in the whole genus.
format	article
author	Anne Friedrich Paul P Jung Jing Hou Cécile Neuvéglise Joseph Schacherer
author_facet	Anne Friedrich Paul P Jung Jing Hou Cécile Neuvéglise Joseph Schacherer
author_sort	Anne Friedrich
title	Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.
title_short	Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.
title_full	Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.
title_fullStr	Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.
title_full_unstemmed	Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.
title_sort	comparative mitochondrial genomics within and among yeast species of the lachancea genus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5d73a3db6f12418db7fee8da696e21ca
work_keys_str_mv	AT annefriedrich comparativemitochondrialgenomicswithinandamongyeastspeciesofthelachanceagenus AT paulpjung comparativemitochondrialgenomicswithinandamongyeastspeciesofthelachanceagenus AT jinghou comparativemitochondrialgenomicswithinandamongyeastspeciesofthelachanceagenus AT cecileneuveglise comparativemitochondrialgenomicswithinandamongyeastspeciesofthelachanceagenus AT josephschacherer comparativemitochondrialgenomicswithinandamongyeastspeciesofthelachanceagenus
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Comparative mitochondrial genomics within and among yeast species of the Lachancea genus.

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