Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

Shaikh Ershadul Haque, Angappan Sheela Materials Chemistry Division, Centre for Nanomaterials, School of Advanced Sciences, VIT University, Vellore, India Abstract: Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, caps...

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Autores principales:	Haque SE, Sheela A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5d73edca418d4429a89a2a2fc089efe1
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spelling	oai:doaj.org-article:5d73edca418d4429a89a2a2fc089efe12021-12-02T05:10:26ZDevelopment of polymer-bound fast-dissolving metformin buccal film with disintegrants1178-2013https://doaj.org/article/5d73edca418d4429a89a2a2fc089efe12015-10-01T00:00:00Zhttps://www.dovepress.com/development-of-polymer-bound-fast-dissolving-metformin-buccal-film-wit-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shaikh Ershadul Haque, Angappan Sheela Materials Chemistry Division, Centre for Nanomaterials, School of Advanced Sciences, VIT University, Vellore, India Abstract: Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, capsules, and syrups for being patient friendly. Buccal films are one such system responsible for systemic drug delivery at the desired site of action by avoiding hepatic first-pass metabolism. Metformin hydrochloride (Met), an antidiabetic drug, has poor bioavailability due to its high solubility and low permeability. The purpose of the study reported here was to develop a polymer-bound fast-dissolving buccal film of metformin to exploit these unique properties. In the study, metformin fast-dissolving films were prepared by the solvent-casting method using chitosan, a bioadhesive polymer. Further, starch, sodium starch glycolate, and microcrystalline cellulose were the disintegrants added to different ratios, forming various formulations (F1 to F7). The buccal films were evaluated for various parameters like weight variation, thickness, folding endurance, surface pH, content uniformity, tensile strength, and percentage of elongation. The films were also subjected to in vitro dissolution study, and the disintegration time was found to be less than 30 minutes for all formulations, which was attributed to the effect of disintegrants. Formulation F6 showed 92.2% drug release within 6 minutes due to the combined effect of sodium starch glycolate and microcrystalline cellulose. Keywords: chitosan, sodium starch glycolate, microcrystalline cellulose, drug-delivery system, immediate releaseHaque SESheela ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Supplement 1 Challenges in biomaterials research, Pp 199-205 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Haque SE Sheela A Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
description	Shaikh Ershadul Haque, Angappan Sheela Materials Chemistry Division, Centre for Nanomaterials, School of Advanced Sciences, VIT University, Vellore, India Abstract: Fast-dissolving drug-delivery systems are considered advantageous over the existing conventional oral dosage forms like tablets, capsules, and syrups for being patient friendly. Buccal films are one such system responsible for systemic drug delivery at the desired site of action by avoiding hepatic first-pass metabolism. Metformin hydrochloride (Met), an antidiabetic drug, has poor bioavailability due to its high solubility and low permeability. The purpose of the study reported here was to develop a polymer-bound fast-dissolving buccal film of metformin to exploit these unique properties. In the study, metformin fast-dissolving films were prepared by the solvent-casting method using chitosan, a bioadhesive polymer. Further, starch, sodium starch glycolate, and microcrystalline cellulose were the disintegrants added to different ratios, forming various formulations (F1 to F7). The buccal films were evaluated for various parameters like weight variation, thickness, folding endurance, surface pH, content uniformity, tensile strength, and percentage of elongation. The films were also subjected to in vitro dissolution study, and the disintegration time was found to be less than 30 minutes for all formulations, which was attributed to the effect of disintegrants. Formulation F6 showed 92.2% drug release within 6 minutes due to the combined effect of sodium starch glycolate and microcrystalline cellulose. Keywords: chitosan, sodium starch glycolate, microcrystalline cellulose, drug-delivery system, immediate release
format	article
author	Haque SE Sheela A
author_facet	Haque SE Sheela A
author_sort	Haque SE
title	Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
title_short	Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
title_full	Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
title_fullStr	Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
title_full_unstemmed	Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
title_sort	development of polymer-bound fast-dissolving metformin buccal film with disintegrants
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/5d73edca418d4429a89a2a2fc089efe1
work_keys_str_mv	AT haquese developmentofpolymerboundfastdissolvingmetforminbuccalfilmwithdisintegrants AT sheelaa developmentofpolymerboundfastdissolvingmetforminbuccalfilmwithdisintegrants
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Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

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