Human hippocampal pre-activation predicts behavior

Abstract The response to an upcoming salient event is accelerated when the event is expected given the preceding events – i.e. a temporal context effect. For example, naming a picture following a strongly constraining temporal context is faster than naming a picture after a weakly constraining tempo...

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Autores principales:	Anna Jafarpour, Vitoria Piai, Jack J. Lin, Robert T. Knight
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5d7698a2c446415c90294abc16116762
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spelling	oai:doaj.org-article:5d7698a2c446415c90294abc161167622021-12-02T16:07:49ZHuman hippocampal pre-activation predicts behavior10.1038/s41598-017-06477-52045-2322https://doaj.org/article/5d7698a2c446415c90294abc161167622017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06477-5https://doaj.org/toc/2045-2322Abstract The response to an upcoming salient event is accelerated when the event is expected given the preceding events – i.e. a temporal context effect. For example, naming a picture following a strongly constraining temporal context is faster than naming a picture after a weakly constraining temporal context. We used sentences as naturalistic stimuli to manipulate expectations on upcoming pictures without prior training. Here, using intracranial recordings from the human hippocampus we found more power in the high-frequency band prior to high-expected pictures than weakly expected ones. We applied pattern similarity analysis on the temporal pattern of hippocampal high-frequency band activity in single hippocampal contacts. We found that greater similarity in the pattern of hippocampal field potentials between pre-picture interval and expected picture interval in the high-frequency band predicted picture-naming latencies. Additional pattern similarity analysis indicated that the hippocampal representations follow a semantic map. The results suggest that hippocampal pre-activation of expected stimuli is a facilitating mechanism underlying the powerful contextual behavioral effect.Anna JafarpourVitoria PiaiJack J. LinRobert T. KnightNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Jafarpour Vitoria Piai Jack J. Lin Robert T. Knight Human hippocampal pre-activation predicts behavior
description	Abstract The response to an upcoming salient event is accelerated when the event is expected given the preceding events – i.e. a temporal context effect. For example, naming a picture following a strongly constraining temporal context is faster than naming a picture after a weakly constraining temporal context. We used sentences as naturalistic stimuli to manipulate expectations on upcoming pictures without prior training. Here, using intracranial recordings from the human hippocampus we found more power in the high-frequency band prior to high-expected pictures than weakly expected ones. We applied pattern similarity analysis on the temporal pattern of hippocampal high-frequency band activity in single hippocampal contacts. We found that greater similarity in the pattern of hippocampal field potentials between pre-picture interval and expected picture interval in the high-frequency band predicted picture-naming latencies. Additional pattern similarity analysis indicated that the hippocampal representations follow a semantic map. The results suggest that hippocampal pre-activation of expected stimuli is a facilitating mechanism underlying the powerful contextual behavioral effect.
format	article
author	Anna Jafarpour Vitoria Piai Jack J. Lin Robert T. Knight
author_facet	Anna Jafarpour Vitoria Piai Jack J. Lin Robert T. Knight
author_sort	Anna Jafarpour
title	Human hippocampal pre-activation predicts behavior
title_short	Human hippocampal pre-activation predicts behavior
title_full	Human hippocampal pre-activation predicts behavior
title_fullStr	Human hippocampal pre-activation predicts behavior
title_full_unstemmed	Human hippocampal pre-activation predicts behavior
title_sort	human hippocampal pre-activation predicts behavior
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5d7698a2c446415c90294abc16116762
work_keys_str_mv	AT annajafarpour humanhippocampalpreactivationpredictsbehavior AT vitoriapiai humanhippocampalpreactivationpredictsbehavior AT jackjlin humanhippocampalpreactivationpredictsbehavior AT roberttknight humanhippocampalpreactivationpredictsbehavior
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Human hippocampal pre-activation predicts behavior

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