Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review

Dan-dan Feng, Tao Tang, Xiang-ping Lin, Zhao-yu Yang, Shu Yang, Zi-an Xia, Yun Wang, Piao Zheng, Yang Wang, Chun-hu ZhangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Feng DD, Tang T, Lin XP, Yang ZY, Yang S, Xia ZA, Wang Y, Zheng P, Zhang CH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	traditional Chinese medicine Chinese herbal formula antidepressant phytochemistry pharmacological bioactivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5d7840c9b7954db687784fb3e5036fb2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5d7840c9b7954db687784fb3e5036fb2
record_format	dspace
spelling	oai:doaj.org-article:5d7840c9b7954db687784fb3e5036fb22021-12-02T04:32:58ZNine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review1178-2021https://doaj.org/article/5d7840c9b7954db687784fb3e5036fb22016-09-01T00:00:00Zhttps://www.dovepress.com/nine-traditional-chinese-herbal-formulas-for-the-treatment-of-depressi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dan-dan Feng, Tao Tang, Xiang-ping Lin, Zhao-yu Yang, Shu Yang, Zi-an Xia, Yun Wang, Piao Zheng, Yang Wang, Chun-hu ZhangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaAbstract: Depression is a major mental disorder, and is currently recognized as the second-leading cause of disability worldwide. However, the therapeutic effect of antidepressants remains unsatisfactory. For centuries, Chinese herbal formulas (CHFs) have been widely used in the treatment of depression, achieving better therapeutic effects than placebo and having fewer side effects than conventional antidepressants. Here, we review the ethnopharmacology, phytochemistry, and pharmacology studies of nine common CHFs: “banxia houpo” decoction, “chaihu shugansan”, “ganmaidazao” decoction, “kaixinsan”, “shuganjieyu” capsules, “sinisan”, “wuling” capsules, “xiaoyaosan”, and “yueju”. Eight clinical trials and seven meta-analyses have supported the theory that CHFs are effective treatments for depression, decreasing Hamilton Depression Scale scores and showing few adverse effects. Evidence from 75 preclinical studies has also elucidated the multitarget and multipathway mechanisms underlying the antidepressant effect of the nine CHFs. Decoctions, capsules, and pills all showed antidepressant effects, ranked in descending order of efficacy. According to traditional Chinese medicine theory, these CHFs have flexible compatibility and mainly act by soothing the liver and relieving depression. This review highlights the effective treatment choices and candidate compounds for patients, practitioners, and researchers in the field of traditional Chinese medicine. In summary, the current evidence supports the efficacy of CHFs in the treatment of depression, but additional large-scale randomized controlled clinical trials and sophisticated pharmacology studies should be performed.Keywords: traditional Chinese medicine, Chinese herbal formula, antidepressant, phytochemistry, pharmacological bioactivityFeng DDTang TLin XPYang ZYYang SXia ZAWang YZheng PWang YZhang CHDove Medical Pressarticletraditional Chinese medicineChinese herbal formulaantidepressantphytochemistrypharmacological bioactivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2387-2402 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	traditional Chinese medicine Chinese herbal formula antidepressant phytochemistry pharmacological bioactivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	traditional Chinese medicine Chinese herbal formula antidepressant phytochemistry pharmacological bioactivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Feng DD Tang T Lin XP Yang ZY Yang S Xia ZA Wang Y Zheng P Wang Y Zhang CH Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
description	Dan-dan Feng, Tao Tang, Xiang-ping Lin, Zhao-yu Yang, Shu Yang, Zi-an Xia, Yun Wang, Piao Zheng, Yang Wang, Chun-hu ZhangLaboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republic of ChinaAbstract: Depression is a major mental disorder, and is currently recognized as the second-leading cause of disability worldwide. However, the therapeutic effect of antidepressants remains unsatisfactory. For centuries, Chinese herbal formulas (CHFs) have been widely used in the treatment of depression, achieving better therapeutic effects than placebo and having fewer side effects than conventional antidepressants. Here, we review the ethnopharmacology, phytochemistry, and pharmacology studies of nine common CHFs: “banxia houpo” decoction, “chaihu shugansan”, “ganmaidazao” decoction, “kaixinsan”, “shuganjieyu” capsules, “sinisan”, “wuling” capsules, “xiaoyaosan”, and “yueju”. Eight clinical trials and seven meta-analyses have supported the theory that CHFs are effective treatments for depression, decreasing Hamilton Depression Scale scores and showing few adverse effects. Evidence from 75 preclinical studies has also elucidated the multitarget and multipathway mechanisms underlying the antidepressant effect of the nine CHFs. Decoctions, capsules, and pills all showed antidepressant effects, ranked in descending order of efficacy. According to traditional Chinese medicine theory, these CHFs have flexible compatibility and mainly act by soothing the liver and relieving depression. This review highlights the effective treatment choices and candidate compounds for patients, practitioners, and researchers in the field of traditional Chinese medicine. In summary, the current evidence supports the efficacy of CHFs in the treatment of depression, but additional large-scale randomized controlled clinical trials and sophisticated pharmacology studies should be performed.Keywords: traditional Chinese medicine, Chinese herbal formula, antidepressant, phytochemistry, pharmacological bioactivity
format	article
author	Feng DD Tang T Lin XP Yang ZY Yang S Xia ZA Wang Y Zheng P Wang Y Zhang CH
author_facet	Feng DD Tang T Lin XP Yang ZY Yang S Xia ZA Wang Y Zheng P Wang Y Zhang CH
author_sort	Feng DD
title	Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
title_short	Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
title_full	Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
title_fullStr	Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
title_full_unstemmed	Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
title_sort	nine traditional chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5d7840c9b7954db687784fb3e5036fb2
work_keys_str_mv	AT fengdd ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT tangt ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT linxp ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT yangzy ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT yangs ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT xiaza ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT wangy ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT zhengp ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT wangy ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview AT zhangch ninetraditionalchineseherbalformulasforthetreatmentofdepressionanethnopharmacologyphytochemistryandpharmacologyreview
_version_	1718401186294398976

Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review

Ejemplares similares